Thomsen-Friedenreich (T) antigen expression increases sensitivity of natural killer cell lysis of cancer cells

International Journal of Cancer. Journal International Du Cancer
John SotiriadisYoon Berm Kim

Abstract

In this study, we demonstrate a correlation between T antigen expression on a panel of human carcinoma cell lines and their sensitivity to porcine NK cell lysis. Specifically, the more T antigen is expressed, the more sensitive the cancer cells are to porcine NK cell lysis. Furthermore, this correlation also exists for these cells and their ability to induce tumors in vivo. In this porcine animal model, the less T antigen is expressed, the more prolific the tumor growth in vivo and vice versa. Using the human colorectal adenocarcinoma cell line SW-48, we used limiting dilution to clone 2 populations of cells, one expressing high and the other low levels of T antigen, clones 143 and 111, respectively. In these cloned cells, the clone that expressed more T antigen was more NK-sensitive in vitro and weakly induced tumor growth in vivo. Inversely, the clone that expressed less T antigen clone was more NK-resistant in vitro and grew more prolific tumors in vivo. Using soluble T antigen in a competitive inhibition assay, there was a decrease in porcine NK cell killing of the T antigen+ human cell line Colo 320HSR. Taken together, these findings suggest a novel role for T antigen in the NK cell recognition of cancer cells, specificall...Continue Reading

References

Aug 1, 1975·Immunochemistry·J Kirschbaum, G F Springer
Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·H M BlottièreJ Le Pendu
Jan 1, 1986·Annual Review of Immunology·R B HerbermanJ R Ortaldo
Oct 1, 1966·Biochemistry·G F SpringerH Tegtmeyer
Feb 28, 1966·Biochimica Et Biophysica Acta·A BezkorovainyK Hotta
Jun 1, 1982·American Journal of Clinical Pathology·J S CoonJ L Summers
Jan 1, 1994·Critical Reviews in Immunology·V Apostolopoulos, I F McKenzie
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·G D MacLeanB M Longenecker
Feb 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B L WangM W Kaufman
Dec 1, 1995·Seminars in Cancer Biology·P O Livingston
Feb 1, 1997·Immunological Reviews·J C Ryan, W E Seaman
Aug 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G F Springer
Nov 14, 1997·Cancer Immunology, Immunotherapy : CII·P O LivingstonK O Lloyd
Feb 14, 1998·International Journal of Cancer. Journal International Du Cancer·J SamuelB M Longenecker
May 20, 1998·Current Topics in Microbiology and Immunology·T L WhitesideR B Herberman
Mar 14, 2000·Current Biology : CB·P Parham
Mar 17, 2000·Immunological Reviews·T Feizi
May 1, 2002·European Journal of Immunology·Lorenzo MorettaAlessandro Moretta
Aug 17, 2002·Current Opinion in Immunology·Karina L McQueen, Peter Parham
Jun 6, 2003·Current Opinion in Immunology·Lewis L Lanier
Dec 20, 2003·The EMBO Journal·Lorenzo Moretta, Alessandro Moretta

❮ Previous
Next ❯

Citations

Jul 18, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyu Hee LimJong-Hoon Kim
Feb 13, 2021·International Journal of Molecular Sciences·Beatriz LeãoCelso A Reis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.