Abstract
Extrapulmonary tuberculosis (EPTB) accounts for ~15% of all TB patients, and TB pleural effusion is the second most common site of EPTB. The diagnosis of pleural TB is challenging due to the pauci-bacillary nature of the disease. Histopathology of thoracoscopically obtained pleural biopsy provides the highest diagnostic yield. The Xpert MTB/RIF assay (Xpert) is a PCR test that can identify both Mycobacterium tuberculosis (MTB) and rifampicin resistance. Currently, there is a lack of clarity regarding the value of Xpert on pleural tissue. We report our experience of using Xpert on thoracoscopic pleural biopsy samples. We retrospectively reviewed the records of patients who underwent thoracoscopy in our institution over a 1-year period. Relevant clinical details; indications; and results of tests on pleural tissue and fluid, including histopathology, mycobacterial cultures and Xpert, were extracted. Of the 156 patients who underwent thoracoscopy, 73 (47%) had TB, 66 (42%) malignancy and 17 (11%) other conditions. Histopathology was diagnostic in all the 73 TB patients (100%). The yields of the microbiological tests against histopathology on thoracoscopic biopsy sample and pleural fluid were: pleural tissue Xpert 45%, pleural tiss...Continue Reading
References
Jan 13, 2004·Journal of Clinical Microbiology·Guy E ThwaitesJeremy J Farrar
Mar 30, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard W Light
Mar 26, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Coenraad F N Koegelenberg, Andreas H Diacon
Dec 14, 2011·Journal of Clinical Microbiology·Raquel MoureFernando Alcaide
Jan 14, 2012·The European Respiratory Journal·Enrico TortoliDaniela M Cirillo
Nov 28, 2012·The European Respiratory Journal·Karin WeyerMario Raviglione
Aug 1, 2013·The European Respiratory Journal·Devasahayam J ChristopherClaudia M Denkinger
Jan 21, 2015·BMC Infectious Diseases·Laura Maynard-SmithStephen D Lawn
Jul 15, 2015·Respiratory Medicine·Zhen WangHuan-Zhong Shi
Jan 29, 2016·Journal of Clinical Microbiology·Inderpaul Singh SehgalRitesh Agarwal
Citations
Oct 30, 2018·Infectious Diseases·Magd Galal El-DinNaira Farghaly
Apr 1, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·David S Hui, Chi-Chiu Leung
Jul 5, 2019·Journal of Clinical Microbiology·Richard MeldauKeertan Dheda
Aug 17, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jane A ShawCoenraad F N Koegelenberg
Aug 19, 2020·Expert Review of Anti-infective Therapy·Mirae Park, Onn Min Kon
Jul 28, 2019·Medwave·Luis Alejandro Rodríguez-HidalgoDiana Cecilia Ruiz-Caballero
Jun 27, 2018·BMC Infectious Diseases·Zhen-Yu Huo, Li Peng
May 26, 2020·BMC Infectious Diseases·Shuguang LiHui Wang
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Dec 17, 2020·Risk Management and Healthcare Policy·Ling GongXiaoping Tang
Oct 31, 2020·Journal of Bronchology & Interventional Pulmonology·Richa GuptaPrince James
Apr 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shan GaoHairong Huang
May 17, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wenwen SunLin Fan
Nov 5, 2021·PloS One·Alberto Garcia-ZamalloaUNKNOWN with the Gipuzkoa Pleura Group Consortium
Dec 18, 2021·Journal of Clinical Laboratory Analysis·Yi-Ran QiuXu-Guang Guo