Thoughts on irritant contact dermatitis

Contact Dermatitis
K E Malten

Abstract

An attempt is made to formulate some kind of working hypothesis concerning the pathophysiology, clinical appearance and treatment of irritant contact dermatitis. Acute irritant dermatitis may be caused by one single overwhelming external exposure of comparatively short duration. It is usually accidental and therefore recognized early as cause and effect. Chronic irritant dermatitis may be the result of a too early repetition of one impairing factor (chronic irritant dermatitis "traumiteration' type), but is more commonly the result of the influence of a variety of stimuli, each starting to be active before recovery from the foregoing stimuli has been completed (chronic irritant dermatitis 'summation' type.) By repetition of the same stimulus, or by a combination of varying stimuli, the degree of impairment surpasses a critical level, in consequence of which a clinical disease (irritant contact dermatitis) ensues. This clinical disease, however, is only 'the tip of the iceberg'. Such stimuli may be chemical, mechanical and/or climatic. To find out which are the harmful factors requires a detailed case history about the patient's work, habits and hobbies, thus enabling him to avoid as many damaging exposures as is practical, and...Continue Reading

References

Feb 1, 1977·Contact Dermatitis·H W RothenborgK E Sjolin
May 1, 1979·Contact Dermatitis·K E MaltenR E Wiggers
Jan 1, 1975·Contact Dermatitis·S Fregert
Dec 1, 1980·Contact Dermatitis·R J Rycroft, W D Smith
Dec 1, 1980·Contact Dermatitis·S Fregert
Jan 1, 1981·Contact Dermatitis·O J ClemmensenP Solgaard
Jan 1, 1981·Contact Dermatitis·J Farkas

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Citations

Jan 1, 1992·Journal of Toxicology. Clinical Toxicology·J HarvellH I Maibach
Feb 22, 1992·BMJ : British Medical Journal·D J Gunnell
Aug 1, 1990·The British Journal of Dermatology·R A TupkerJ P Nater
Jan 1, 1985·American Journal of Industrial Medicine·T Fischer, I Rystedt
Feb 1, 1996·Contact Dermatitis·V GoffinG E Piérard
Jul 4, 2003·International Journal of Dermatology·Surjit Singh Mehta, Belum Siva Nagi Reddy
Jun 22, 2006·Contact Dermatitis·Cindy M De JonghSanja Kezic
Aug 22, 2006·Contact Dermatitis·Flemming AndersenKlaus Ejner Andersen
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Andrea BauerHywel C Williams
Dec 17, 2010·Archives of Dermatological Research·Marty O VisscherR Randall Wickett
Apr 30, 2015·American Journal of Clinical Dermatology·Dimitar AntonovPeter Elsner
Oct 11, 2017·Alternatives to Laboratory Animals : ATLA·Christa RaakThomas Ostermann
Sep 1, 1991·International Journal of Dermatology·M M BasonH I Maibach
May 1, 1985·Clinical and Experimental Dermatology·P G van der ValkM C de Jong
May 1, 1988·International Journal of Dermatology·K Lammintausta, H I Maibach
Jul 17, 1998·Contact Dermatitis·D A BasketterA Lahti
Aug 1, 1998·Contact Dermatitis·W GehringP Kleesz
Jun 10, 2004·Contact Dermatitis·F H W JungbauerP J Coenraads
Nov 15, 2005·Contact Dermatitis·Nara BrancoHoward I Maibach
Jan 12, 2008·The Australasian Journal of Dermatology·Dan SlodownikRosemary Nixon
Jan 18, 2008·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·David Voegeli
Apr 22, 2008·The British Journal of Dermatology·D A BasketterI R White
Jul 16, 2010·The Journal of Dermatology·Virendra N SehgalAlpna D Sharma
May 1, 2018·The Cochrane Database of Systematic Reviews·Andrea BauerHywel C Williams
Apr 1, 1995·Contact Dermatitis·A M GrunewaldP Kleesz
Feb 1, 1995·Contact Dermatitis·E BerardescaG Rabbiosi
Nov 1, 1984·Contact Dermatitis·I PevnyG Razinskas
Sep 1, 1986·Contact Dermatitis·D J GawkrodgerJ A Hunter
Nov 1, 1988·Clinical and Experimental Dermatology·C L Goh, K L Phay
Jun 10, 2004·Dermatologic Therapy·Robert L Rietschel

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