Abstract
We encountered three adult patients with flu-like symptoms diagnosed with human parvovirus B19 (HPV-B19) infection. Blood serum analysis also revealed leukopenia, with white blood cell counts (WBCs) of 1,000-2,000/mL and low platelet counts of 89-150 × 10(9)/L. Typical skin rash was absent in one patient. Bone marrow examination of another patient showed hypoplastic marrow with <5% blast cells. All patients recovered without administration of granulocyte colony-stimulating factor (G-CSF). Therefore, HPV-B19 infection with leukopenia should be considered in adult patients with leukopenia during erythema infectiosum epidemics, even if typical clinical findings (ie, skin rash) are absent. Further, the fact that three cases were observed over the stated time period at our hospital, which is located in Nagoya city, showed a transition to a slightly higher level of incidence than the annual average.
References
May 9, 1992·Lancet·K MuirE Fitzsimons
Feb 1, 1992·British Journal of Haematology·J PontN Honetz
Apr 18, 1990·JAMA : the Journal of the American Medical Association·S M GillespieE S Hurwitz
Aug 1, 1985·The Journal of Infectious Diseases·M J AndersonD A Tyrrell
Apr 1, 1995·British Journal of Haematology·K Shirono, H Tsuda
Oct 1, 1993·Science·K E BrownN S Young
Sep 1, 1993·British Journal of Haematology·K McClainD H Mahoney
Jun 1, 1996·Acta Paediatrica Japonica; Overseas Edition·H Wakamoto, M Miyazaki
Apr 1, 1997·Hematology and Cell Therapy·E GautierG Tchernia
Jun 7, 2000·The Journal of Infection·G D Barlow, M W McKendrick
May 8, 2002·Internal Medicine·Hitoshi HayakawaMitsuhiro Osame
Jul 18, 2002·Dermatologic Clinics·Rajani Katta
Feb 6, 2004·The New England Journal of Medicine·Neal S Young, Kevin E Brown
Jan 26, 2005·European Journal of Internal Medicine·Valery IstominDavid Hassin
Feb 16, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Mariko SeishimaChikako Arakawa
Citations
Nov 4, 2016·Clinical Microbiology Reviews·Jianming QiuNeal S Young
Jan 26, 2021·Curēus·Elona ShehiCosmina Zeana
Mar 7, 2021·Journal of Clinical Medicine·Matthijs RaadsenMarco Goeijenbier
Apr 27, 2021·British Journal of Haematology·Mahmoud I ElbadryAhmed Tawfeek