Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury.

Frontiers in Physiology
Bradford J SmithJason H T Bates

Abstract

Mechanical ventilation is an essential lifesaving therapy in acute respiratory distress syndrome (ARDS) that may cause ventilator-induced lung injury (VILI) through a positive feedback between altered alveolar mechanics, edema, surfactant inactivation, and injury. Although the biophysical forces that cause VILI are well documented, a knowledge gap remains in the quantitative link between altered parenchymal structure (namely alveolar derecruitment and flooding), pulmonary function, and VILI. This information is essential to developing diagnostic criteria and ventilation strategies to reduce VILI and improve ARDS survival. To address this unmet need, we mechanically ventilated mice to cause VILI. Lung structure was measured at three air inflation pressures using design-based stereology, and the mechanical function of the pulmonary system was measured with the forced oscillation technique. Assessment of the pulmonary surfactant included total surfactant, distribution of phospholipid aggregates, and surface tension lowering activity. VILI-induced changes in the surfactant included reduced surface tension lowering activity in the typically functional fraction of large phospholipid aggregates and a significant increase in the pool o...Continue Reading

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Citations

Nov 17, 2020·Frontiers in Physiology·Vitor MoriJason H T Bates
Oct 19, 2021·Frontiers in Physiology·Deepak K AgrawalDavid J Albers
Oct 31, 2021·Laboratory animal research·Jon Petur JoelssonSigurbergur Karason

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Methods Mentioned

BETA
imaging techniques
bronchoalveolar lavage
confocal microscopy

Software Mentioned

PMCMR
NewCast
NLME
MATLAB
R
Stereo Investigator
lsmeans

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