Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis

Hypertension
R Y ZeeK Lindpaintner

Abstract

Unexplained, persistent cough limits the use of angiotensin-converting enzyme (ACE) inhibitors in a significant number of patients. It has been speculated that occurrence of this adverse effect is genetically predetermined; in particular, variants of the genes encoding ACE, chymase, and B2-bradykinin receptor have been implicated. To investigate this question, we determined genotypes for common polymorphisms for these three genes in subjects with a history of ACE inhibitor-related cough. Specificity of the adverse effect was confirmed by a blinded, double-crossover design protocol in which subjects were rechallenged with either lisinopril or placebo. In 99 case subjects and 70 control subjects (who failed to develop cough on rechallenge with ACE inhibitor) thus selected, frequencies for the ACE D and I alleles were 0.56 and 0.44 (cases) and 0.56 and 0.44 (controls), respectively; frequencies for chymase A and B alleles (absence/presence of BstXI site) were 0.56 and 0.44 (cases) and 0.46 and 0.54 (controls), respectively; frequencies for B2-bradykinin receptor + and - alleles (presence/absence of a 21 to 29 nonanucleotide sequence) were 0.52 and 0.48 (cases) and 0.53 and 0.47 (controls), respectively. All observed genotype frequ...Continue Reading

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Citations

Sep 12, 2000·Current Hypertension Reports·M Knoblauch, K Lindpaintner
Aug 29, 2006·Journal of Feline Medicine and Surgery·Yumi Ishikawa Jun Ugai
Nov 10, 2009·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
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Jan 13, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Huimin YuGuozhang Liu
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koh-ichi SakamotoAkio Fujimura
Feb 12, 2013·Pharmacogenomics·Seyed Hamidreza MahmoudpourAnke H Maitland-van der Zee
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Sep 24, 2005·Journal of Pharmacological Sciences·Marie Eve MoreauAlbert Adam
Jul 21, 2006·Annals of the New York Academy of Sciences·Gian Paolo Rossi, Gisella Pitter

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