Three cases of clear-cell adenocarcinoma arising from endometrioma during hormonal treatments

The Journal of Obstetrics and Gynaecology Research
Osamu YoshinoShigeru Saito

Abstract

Endometrioma is known to be an occurrence site of ovarian cancer, but there is no evidence on how to reduce the risk of canceration. Here, we report three cases of ovarian cancer arising from endometrioma during hormone therapies of GnRH analogue and tamoxifen, low-dose estrogen-progestin (LEP) and dienogest. In all cases, each hormonal treatment was effective in shrinking the size of the endometrioma. During hormonal treatments, solid parts inside endometrioma were observed, which was followed by surgery. The histology of the solid parts was clear-cell adenocarcinoma in all cases. An immunohistochemistry study demonstrated that the estrogen receptor (ER) and progesterone receptor (PR) were positive in the endometriosis part but negative in the cancer part, while the human EGF receptor (HER) 2 was negative or very weak in the benign part and positive in the malignant part in all three cases. Even though hormonal treatments seem to be effective to regulate endometrioma, careful observation is needed to follow-up patients with endometrioma.

References

Jul 25, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggageD D Boyle
Nov 28, 2000·Gynecologic and Obstetric Investigation·E J Thomas, I G Campbell
May 12, 2001·The Breast Journal·T. Scott JenningsTimothy M. Smith
Nov 21, 2002·Gynecologic and Obstetric Investigation·Jaques DonnezMireille Smets
Apr 23, 2003·Molecular and Cellular Endocrinology·Jennifer R SchultzAnn M Nardulli
Jun 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T BeseM Arvas
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H KobayashiT Terao
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Ryuji KawaguchiHiroshi Kobayashi
Jan 24, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi KobayashiHidekazu Oi
Mar 17, 2011·The Oncologist·Leonel F Hernandez-Aya, Ana M Gonzalez-Angulo
Oct 8, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jian-Jun WeiSerdar Bulun
Aug 22, 2013·Journal of the Chinese Medical Association : JCMA·Chiung-Ru LaiAnna Fen-Yau Li
Oct 10, 2013·The Journal of Obstetrics and Gynaecology Research·Nozomi OuchiToshiyuki Takeshita
Jan 18, 2014·Human Reproduction·G A J DunselmanUNKNOWN European Society of Human Reproduction and Embryology
Feb 8, 2014·Gynecologic and Obstetric Investigation·Fuminori TaniguchiNaoki Terakawa
Aug 21, 2016·Fertility and Sterility·Hirofumi HaraguchiYutaka Osuga
Aug 28, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Line H ThomsenJan Blaakaer
Apr 27, 2017·Reproductive Sciences·Fuminori ItoHiroshi Kobayashi

❮ Previous
Next ❯

Citations

Sep 2, 2019·International Journal of Clinical Oncology·Kosuke MurakamiNoriomi Matsumura
Feb 3, 2021·Antioxidants·Tsukuru AmanoTokuhiro Chano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Related Papers

Acta Obstetricia Et Gynecologica Scandinavica
Anna-Sofia MelinA Bergqvist
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Hui ZhengXiao-ye Lu
© 2022 Meta ULC. All rights reserved