PMID: 6408661Jan 1, 1983Paper

Three-choice drug discrimination: phencyclidine-like stimulus effects of opioids

Psychopharmacology
J M White, S G Holtzman

Abstract

To assess the commonalities and differences in the discriminative stimulus properties of phencyclidine (PCP) and psychotomimetic opioids, rats were trained to discriminate PCP (2.0 mg/kg), cyclazocine (1.0 mg/kg), and saline in a three-choice discrete-trial avoidance paradigm. Stimulus control of behavior, defined as the reliable completion of 18 trials of a 20-trial session on the appropriate choice lever after administration of PCP, cyclazocine, or saline, was established in an average of 157 sessions. In tests of stimulus generalization, SKF-10,047 and dextrorphan engendered lever choices appropriate to both PCP and cyclazocine, sometimes in the same animal and at the same dose. The rats responded almost exclusively on the PCP-appropriate lever after ketamine and on the saline lever after morphine and d-amphetamine, indicating pharmacologic specificity. Naltrexone, in doses that had little effect on stimulus control of behavior by PCP, completely blocked cyclazocine-like stimulus control. Decreases in cyclazocine choices in the presence of naltrexone were associated with increases in PCP choices. These results support conclusions derived from two-choice procedures that psychotomimetic opioids have PCP-like stimulus effects, ...Continue Reading

References

Nov 15, 1977·Psychopharmacology·I D Hirschhorn
Nov 10, 1976·Psychopharmacology·H E Shannon, S G Holtzman
Dec 28, 1981·Life Sciences·R S Zukin, S R Zukin
Nov 7, 1980·European Journal of Pharmacology·J J Teal, S G Holtzman
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R QuirionC B Pert

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Citations

Feb 11, 1986·European Journal of Pharmacology·P C ContrerasT L O'Donohue
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·G T BolgerP Skolnick
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·D A OvertonD A Merkle
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B L LargentS H Snyder
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E WeberJ F Keana
Mar 23, 2013·Journal of Addiction Medicine·Danielle Baribeau, Keyghobad Farid Araki
Feb 1, 1985·Drug and Alcohol Dependence·S G Holtzman
Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·T U Järbe
Aug 22, 2021·Behavioural Pharmacology·Gail Winger

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