PMID: 7031215Dec 1, 1981Paper

Three-day therapy of lower urinary tract infections with nitrofurantoin macrocrystals: a randomized clinical trial

The Journal of Pediatrics
J A LohrM D Dickens

Abstract

Forty-nine girls between the ages of 2 and 18 years with a symptomatic urinary tract infection documented by two clean-catch urine cultures completed a double-blind study comparing the effectiveness of three days versus ten days of nitrofurantoin macrocrystal therapy. Localization of the infection to the lower urinary tract was presumed on the basis of clinical presentation. All patients had sterile urine on day two or three of therapy. In the ten-day group, two of 23 patients (8.7%) experienced a single relapse, and seven patients (30%) had 12 episodes of reinfection during a six-month follow-up. In the three-day group, two of 26 patients (7.7%) had a single relapse, and six patients (23%) had 12 episodes of reinfection. The rates of relapse and reinfection in the compared groups were not statistically significantly different (P greater than 0.05). Three days of treatment with nitrofurantoin macrocrystals is an effective regimen for symptomatic girls presumed to have uncomplicated lower urinary tract infections.

References

Oct 1, 1979·The Urologic Clinics of North America·W B Lorentz
May 5, 1979·British Medical Journal·G Källenius, J Winberg
Apr 26, 1976·JAMA : the Journal of the American Medical Association·A R RonaldH Mourtada
Mar 1, 1975·Acta paediatrica Scandinavica·U JodalK Lincoln
Sep 9, 1967·British Medical Journal·R N Grüneberg, W Brumfitt

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Citations

Jan 1, 1991·International Urology and Nephrology·G Jójárt
Oct 1, 1982·The Journal of Pediatrics·C Godard, P Girardet
Oct 6, 1997·Infectious Disease Clinics of North America·T M Hooton, W E Stamm
Sep 1, 1984·Annals of Emergency Medicine·G E StahlA B Gruskin
Apr 1, 1983·The Journal of Pediatrics·E D AvnerR H Rubin
Jan 22, 2003·The Cochrane Database of Systematic Reviews·M MichaelV A Moyer
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Anita FitzgeraldKjell Tullus
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·I Helin

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