Abstract
Albendazole therapy has been found effective in solitary cysticercus granuloma. An optimal duration of albendazole therapy is not exactly known. Even 3-day therapy has been found effective. We included 105 patients of new-onset seizures and solitary cysticercus granuloma. We compared 3-day albendazole therapy and 15-day therapy with a control group. Each group had 35 patients. This was an open-label randomized trial. Patients were followed for 6 months. MRI was done after 6 months. Seizure recurrences during follow-up were noted. After 6 months, albendazole group, in comparison to placebo group, had significantly higher proportion (43/70 versus 13/35) of patients in whom lesion had disappeared. Albendazole treatment for 15 days was insignificantly better in comparison to 3-day treatment regimen. In 15-day albendazole group lesser number of lesions (2.8%) was calcified than 3-day albendazole group (8.57%) or no treatment group (20%). After 6 months of follow-up, seizure recurrence was seen in 20 (19%) patients. The majority (15/20) of patients, experiencing seizure recurrence, had an abnormal follow-up MRI. Five patients had seizures despite normal MRI. In conclusion, albendazole was significantly better in producing lesion reso...Continue Reading
References
May 1, 1985·Neurology·J SoteloJ Rodriguez-Carbajal
Sep 3, 1998·The Pediatric Infectious Disease Journal·A K BaranwalS C Singhi
Sep 19, 1998·Journal of the Neurological Sciences·J M Murthy, Y V Subba Reddy
Oct 17, 1998·Epilepsia·A CarpioW A Hauser
Mar 14, 2003·The Pediatric Infectious Disease Journal·Pratibha SinghiN Khandelwal
Jan 16, 2004·The New England Journal of Medicine·Héctor H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jul 3, 2004·Australasian Radiology·Irfan RobbaniKamal K Pandita
Jun 2, 2005·Neurosurgical Focus·Ravindra Kumar Garg
Aug 5, 2006·Epilepsia·Tracy GlauserTorbjorn Tomson
Feb 7, 2008·Expert Review of Anti-infective Therapy·Ravindra Kumar Garg
Oct 31, 2009·Journal of the Neurological Sciences·A de SouzaK Thennarasu
Dec 3, 2009·Acta Neurologica Scandinavica·D GoelA Singhal
Aug 27, 2010·Neurology India·Gagandeep Singh, J M K Murthy
Dec 22, 2010·Neurology·G SinghH H Garcia
Citations
Sep 4, 2015·International Journal for Parasitology·Aloukick K SinghKashi N Prasad
Oct 4, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Matthew L RomoUNKNOWN Ecuadorian Neurocysticercosis Group
Dec 3, 2014·Veterinary Parasitology·Sónia M S AfonsoBettencourt P S Capece
Jun 19, 2012·Expert Review of Anti-infective Therapy·Ravindra Kumar Garg, Hardeep Singh Malhotra
Jun 2, 2021·The Cochrane Database of Systematic Reviews·Edward J M MonkLakshmi N Ranganathan