Three Different Optical Coherence Tomography Angiography Measurement Methods for Assessing Capillary Density Changes in Diabetic Retinopathy

Ophthalmic Surgery, Lasers & Imaging Retina
Alexandre PedinielliRamin Tadayoni

Abstract

To compare capillary density (CD) changes assessed by optical coherence tomography angiography (OCTA) during diabetic retinopathy (DR) progression using three previously published methods: binarization, skeletonization, and automated flow density (AFD). Retrospective study of 98 eyes of 74 patients with diabetes and 18 control eyes imaged using OCTA. The macular CD at each stage of DR was assessed using the three methods and were compared to control eyes. AFD was the only method that detected differences between controls and severe nonproliferative DR eyes. The three methods showed a significant difference in CD between controls and eyes with proliferative DR, except for the "fovea" area. Only one of the three methods allowed for the detection of changes from the normal capillary density as early as at the "severe nonproliferative DR" stage due to several refinements from the basic technique. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:378-384.].

References

Jan 1, 1993·Retina·A M MansourR Haymond
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
May 30, 2015·Investigative Ophthalmology & Visual Science·Jian YuXinghuai Sun
Jan 10, 2016·American Journal of Ophthalmology·Wilfried MinvielleEric H Souied
Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Di GongFangtian Dong

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Citations

Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
May 16, 2019·Retina·Carlo LaviaBénédicte Dupas
Sep 2, 2020·Ocular Immunology and Inflammation·Hyun Goo KangChristopher Seungkyu Lee
Sep 1, 2018·Investigative Ophthalmology & Visual Science·Mohammed AshrafAmani A Fawzi
Dec 27, 2018·International Ophthalmology Clinics·Jeffrey TranChristina Y Weng

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Software Mentioned

SPSS
GNU Image Manipulation Program ( GIMP
OCTA
AngioVue
ImageJ

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