Three-dimensional analysis of right ventricular shape and function in pulmonary hypertension.

Pulmonary Circulation
Peter J LearyFlorence H Sheehan

Abstract

Right ventricular (RV) failure is a key determinant of morbidity and mortality in pulmonary hypertension (PH). The present study aims to add to existing descriptions of RV structural and functional changes in PH through a comprehensive three-dimensional (3D) shape analysis. We performed 3D echocardiography on 53 subjects with PH and 19 normal subjects. Twenty short-axis slices from apex to tricuspid centroid were measured to characterize regional shape: apical angle, basal bulge, eccentricity, and area. Transverse shortening was assessed by fractional area change (FAC) in each short-axis slice, longitudinal contraction was assessed by tricuspid annular plane systolic excursion (TAPSE) and global function by RV ejection fraction. Multivariate logistic analysis was used to compare the association of RV parameters with New York Heart Association (NYHA) class. Compared to normal, RV function in PH is characterized by decreased stroke volume index (SVi), fractional area change and ejection fraction. Increased eccentricity, apical rounding and bulging at the base characterize the shape of the RV in PH. Increased SVi, ejection fraction and mid-ventricular FAC were associated with less severe NYHA class in adjusted analyses. The RV in ...Continue Reading

References

Jul 11, 2002·The International Journal of Cardiovascular Imaging·Michal HubkaFlorence H Sheehan
Sep 3, 2002·Journal of the American College of Cardiology·Olivier SitbonGérald Simonneau
Jan 12, 2005·The American Journal of Cardiology·Steven M KawutRobyn J Barst
Dec 13, 2005·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Jesper KjaergaardChristian Hassager
May 12, 2006·Echocardiography·Angel López-CandalesRaveen Bazaz
Aug 5, 2006·American Journal of Respiratory and Critical Care Medicine·Paul R ForfiaPaul M Hassoun
Jan 24, 2007·European Heart Journal·Serge A van WolferenAnton Vonk-Noordegraaf
Jul 10, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Carly JenkinsThomas H Marwick
Aug 19, 2007·International Journal of Cardiology·Angel López-CandalesKathy Edelman
Dec 26, 2007·The American Journal of Cardiology·Florence H SheehanAlan H Stolpen
Jan 25, 2008·The European Respiratory Journal·M J OverbeekA Vonk-Noordegraaf
Oct 22, 2008·Heart·Florence Sheehan, Andrew Redington
Mar 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Makoto AmakiMasafumi Kitakaze
Jul 9, 2009·Journal of the American College of Cardiology·Gérald SimonneauRogério Souza
Sep 25, 2010·Chest·Serge A van WolferenAnton Vonk Noordegraaf
Oct 7, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Steven M KawutDavid A Bluemke
Feb 26, 2011·Journal of the American College of Cardiology·Mardi Gomberg-MaitlandRaymond L Benza
Oct 18, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ivan S SalgoRoberto M Lang

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Citations

Mar 7, 2014·American Journal of Respiratory and Critical Care Medicine·Peter J LearySteven M Kawut
Oct 19, 2013·Current Hypertension Reports·Jinghui LiYingsheng Cheng
Dec 14, 2012·European Heart Journal Cardiovascular Imaging·Luc Mertens, Kendall Hunter
Jan 22, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hadas ShiranPhillip C Yang
Nov 3, 2015·Echocardiography·Nicole PristeraBrian D Hoit
Dec 18, 2015·Cardiology in the Young·Michael P DiLorenzoLaura Mercer-Rosa
Apr 11, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Daniel S KnightJ Gerry Coghlan
Jul 15, 2015·European Heart Journal Cardiovascular Imaging·Karima AddetiaRoberto M Lang
Feb 5, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Miriam WheelerJasmine Grewal
Apr 3, 2012·International Journal of Cardiology·Christopher M LeePhilip J Kilner
Nov 14, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·John SimpsonGirish Shirali
Aug 16, 2018·American Journal of Respiratory and Critical Care Medicine·Tim LahmUNKNOWN American Thoracic Society Assembly on Pulmonary Circulation
Jul 19, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Charlène MaugerAlistair A Young
Dec 20, 2019·The International Journal of Cardiovascular Imaging·Bing-Yang LiuChang-Ming Xiong
Dec 4, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pei-Ni JonePamela Moceri
Mar 12, 2021·Journal of Biomechanical Engineering·Alifer Bordones-CromEnder Finol

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