Three dimensional analysis of the lamina cribrosa in glaucoma

The British Journal of Ophthalmology
J Morgan-DaviesA Azuara-Blanco

Abstract

Structural changes in the lamina cribrosa have been implicated in the pathogenesis of glaucomatous optic atrophy. The aim of this study was to determine a measure the surface variability of the cup floor in normal subjects and patients with glaucoma. A sample of age matched normal subjects (NN), patients with low tension glaucoma (LTG), and primary open angle glaucoma (POAG) were included in the study. The glaucoma groups were matched for the severity of the visual field loss. Mean 10 degree topographic images of normal and glaucomatous eyes from the Heidelberg retina tomograph were imported into ERDAS image processing software where topographic analysis of the cup floor could be assessed. Each image was processed using customised spatial filters that calculated the surface depth variation in localised neighbourhood areas across each image. The local change in depth across the cup floor surface was determined and compared between the three clinical groups. The depth variation in the cup floor was largest in normal subjects followed by LTG and POAG. Highly statistically significant differences in surface depth variability of the cup floor existed between normal and LTG (p = 0.005), between normal and POAG (p<0.0001), and between...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J YamagamiS Shirato
Aug 1, 1985·Archives of Ophthalmology·J Caprioli, G L Spaeth
Dec 1, 1981·Archives of Ophthalmology·R L Radius, M Gonzales
Oct 1, 1982·Archives of Ophthalmology·R L Radius, B Bade
Mar 1, 1981·Archives of Ophthalmology·R L Radius
Sep 30, 2000·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Morgan-DaviesC J O'Brien

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Citations

Jul 14, 2012·PloS One·Mitsuko TakamotoKatsushi Tokunaga
Feb 11, 2014·Mathematical Biosciences and Engineering : MBE·Giovanna GuidoboniBrent A Siesky
Oct 4, 2015·Progress in Retinal and Eye Research·Helen V Danesh-MeyerColin R Green
Mar 8, 2016·American Journal of Ophthalmology·Chunwei ZhangFelipe A Medeiros
Feb 14, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ying-Shan ChenIlva D Rupenthal
Sep 15, 2011·Acta Ophthalmologica·Tetsuya MoritaKimiya Shimizu
Jun 26, 2012·Medical Hypotheses·Xin WeiXuyang Liu
Oct 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Sung C Park, Robert Ritch
Jul 13, 2007·Experimental Eye Research·Ian A SigalC Ross Ethier
Oct 23, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J MatlachV Prokosch-Willing
Dec 26, 2017·Current Genetic Medicine Reports·Nicole A Restrepo, Jessica N Cooke Bailey
Jun 19, 2018·European Journal of Ophthalmology·Gema RebolledaFrancisco J Muñoz-Negrete
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Abhiram S VilupuruAustin Roorda
Oct 8, 2019·Translational Vision Science & Technology·Pranjal S TaskarSoumyajit Majumdar
Feb 7, 2021·Survey of Ophthalmology·Julia Corradi F AndradeTiago S Prata
Sep 1, 2012·Journal of Current Glaucoma Practice·Brenda NuyenRobert N Weinreb
Nov 28, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Benedict HughesPreetha Muthayya
Aug 18, 2021·Veterinary Ophthalmology·Shin Ae Park, András M Komáromy

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