Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis

Hearing Research
S TakeuchiA Kakigi

Abstract

Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional distribution of intermediate cells. These cells constituted a honeycomb-like network, and their dendritic processes surrounded not only capillaries but also the basolateral surface of epithelial marginal cells. On the basis of the above finding and the large K(+) conductance in intermediate cells, we propose that the network composed of intermediate cells has a spatial K(+) buffering function. Transmission electron microscopy revealed the absence of the basal lamina in some regions and the presence of a gap junction-like membrane association between intermediate cells and pericytes and/or endothelial cells. This result supported our previous finding that intermediate cells were dye-coupled with pericytes and endothelial cells. The presence of gap junctions between intermediate cells and pericytes and/or endothelial cells suggests that endothelial cells and pericytes may play roles other than forming a structural r...Continue Reading

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Citations

Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wenjing ZhangXiaorui Shi
Aug 7, 2008·Journal of Cell Science·Takatoshi KarasawaPeter S Steyger
Apr 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Martine Cohen-SalmonChristine Petit
Aug 31, 2011·Hearing Research·Xiaorui Shi
Mar 6, 2015·Cell and Tissue Research·Lingling NengXiaorui Shi
Feb 25, 2014·Neurobiology of Disease·Taku ItoAndrew J Griffith
Jul 5, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chun-Chen PanYan-Ling Tao
Nov 30, 2016·International Journal of Immunopathology and Pharmacology·Andrea CiorbaStavros Hatzopoulos
Oct 15, 2018·Journal of Cellular Physiology·Giovanni GiurdanellaSalvatore Salomone
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Daniel C MarcusPaulo Kofuji
Oct 11, 2017·Molecular Medicine Reports·Wenjing ZhangZhaobing Qin
Jul 3, 2021·International Journal of Molecular Sciences·Parveen BazardBo Ding
Dec 18, 2007·Hearing Research·Chun Fu Dai, Peter S Steyger

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