Three-Dimensional Cell Cultures in Drug Discovery and Development.

SLAS Discovery
Ye Fang, Richard M Eglen

Abstract

The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles.

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Methods Mentioned

BETA
chip
bioprinting
imaging technique
biosensor
biopsies
fluorescence imaging
imaging techniques

Software Mentioned

ViaCytes

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