Three-dimensional combination of transrectal and transperineal biopsies for efficient detection of stage T1c prostate cancer.

International Journal of Clinical Oncology
Satoru KawakamiKazunori Kihara

Abstract

Although an increasing number of men present with stage T1c prostate cancer, the optimal biopsy strategy for detecting stage T1c disease still remains to be defined. The aim of this study was to explore an efficient first-time biopsy scheme for detecting stage T1c and T2 prostate cancer. A transrectal ultrasound-guided systematic three-dimensional 26-core (3D26) biopsy comprising 12 transrectal and 14 transperineal sampling sites was performed in 321 men with median prostate-specific antigen (PSA) level of 6.0 ng/ml in the first-time biopsy setting. By analyzing site-specific cancer detection rates, we determined the best combination of transperineal and transrectal sampling sites. Prostate cancer was detected in 109 of the 321 men (34%) with a major complication rate of 0.6%. 3D26 biopsy significantly improved cancer detectability by 60% relative to the conventional transrectal sextant (TR6) biopsy. Improvement was significant in 263 men with normal digital rectal examination (DRE) (85%, P = 0.0004) but not in 58 men with abnormal DRE (22%, P = 0.18). The mean Gleason score of the 41 cancers without a positive core within the TR6 sites was marginally lower than that of 68 cancers with a positive core within the TR6 sites (P = ...Continue Reading

References

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Aug 3, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru KawakamiYukio Kageyama
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Citations

Mar 27, 2013·International Urology and Nephrology·Hideki TakeshitaKazunori Kihara
Sep 26, 2013·Nature Reviews. Urology·Dwayne T S ChangNathan Lawrentschuk
Nov 24, 2011·Prostate Cancer·J L Dominguez-EscrigD Greene
May 7, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuichi KuboKazunori Kihara
Jan 6, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Noboru NumaoKazunori Kihara
Dec 5, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru KawakamiKazunori Kihara
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru KawakamiIwao Fukui
Apr 5, 2013·BJU International·James L SymonsPhillip D Stricker
Apr 16, 2014·BJU International·Hideki TakeshitaKazunori Kihara
Apr 27, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru Kawakami
Oct 3, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Masahito SuzukiKazunori Kihara
Mar 26, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaya ItoKazunori Kihara
Aug 4, 2016·Cardiovascular and Interventional Radiology·Ali Babaei JandaghiRamin Pourghorban

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