Three-dimensional compositional analysis of drug eluting stent coatings using cluster secondary ion mass spectrometry

Analytical Chemistry
Christine M MahoneyA M Belu

Abstract

Cluster secondary ion mass spectrometry (cluster SIMS) employing an SF5+ polyatomic primary ion sputter source in conjunction with a Bi3+ analysis source was used to obtain three-dimensional molecular information in polymeric-based drug-eluting stent coatings. The formulations of the coatings varied from 0% to 50% (w/w) sirolimus drug in poly(lactic-co-glycolic acid) and were prepared on both MP35N metal alloy coupons and bare metal stents. All cluster SIMS depth profiles obtained indicated a drug-enriched surface region, followed by a drug-depletion region, and finally a constant bulk composition region, similar to previous data obtained in polymeric blend systems. The drug overlayer thickness was determined to increase with increasing sirolimus content. Sample temperature was determined to play an important role in the resulting depth profiles, where it was shown that the best profiles were obtained at low temperatures (-100 degrees C). At these temperatures, molecular signals typically remained constant through the entire depth of the film (approximately 6.5 microm) in some cases, as opposed to the typical 1 microm-2 microm depth limit, which is achievable at room temperature. The 3-D imaging capabilities of cluster SIMS wer...Continue Reading

References

Feb 22, 2005·International Journal of Cardiology·Barend L van der HoevenJ Wouter Jukema
Aug 18, 2005·Rapid Communications in Mass Spectrometry : RCM·Bart BoschmansLuc Van Vaeck

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Citations

Dec 29, 2013·Analytica Chimica Acta·Anna C CreceliusUlrich S Schubert
Apr 26, 2011·Journal of Proteomics·Tyler GreerLingjun Li
Jan 22, 2010·Journal of Pharmaceutical Sciences·Martin K McDermottCarolyn N Witkowski
May 12, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ali RafatiMorgan R Alexander
Jan 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna BeluKlaus Wormuth
Feb 24, 2012·Journal of Mass Spectrometry : JMS·Jiun-Tang HuangGyorgy Vas
Sep 14, 2011·Rapid Communications in Mass Spectrometry : RCM·Yun-Wen YouJing-Jong Shyue
Jan 4, 2010·Macromolecular Rapid Communications·Mark M BaileyCory Berkland
May 19, 2009·Mass Spectrometry Reviews·Christine M Mahoney
Jun 25, 2009·Analytical Chemistry·Veronica PinnickEmile A Schweikert
May 25, 2010·Analytical Chemistry·Steffen M Weidner, Sarah Trimpin
Aug 18, 2012·Analytical Chemistry·Alexander G ShardRudolf Moellers
Apr 1, 2020·Journal of the American Society for Mass Spectrometry·Yanwen ChenBin Li
Apr 27, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Kevin B BiggsCynthia A Maryanoff

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