Three-dimensional computer model of the heart: fibrillation induced by extrastimulation.

Computers and Biomedical Research, an International Journal
N V Thakor, L N Eisenman

Abstract

We present a three-dimensional (3D) computer model that simulates electrical activity in the heart during fibrillation. A real dog heart is discretized to form 1473 interconnected cubic elements. The model exhibits normal activation and recovery from pacing. Five or more extrastimuli induce a self-sustaining tachyarrhythmia that soon degenerates into a fibrillatory rhythm. The extrastimuli increase the excitability of the myocardial cell population. The result is a rapid re-excitation of cells that allows for only a partial recovery of cell action potential. This suggests that a dispersion of refractory states of the cell population is the cause of fibrillation in this computer model.

References

Aug 1, 1987·Computers and Biomedical Research, an International Journal·H AhlfeldtO Wigertz
Jun 1, 1970·Circulation·D DurrerR C Arzbaecher
Nov 1, 1970·The Journal of Physiology·S Weidmann
Dec 1, 1983·IEEE Transactions on Bio-medical Engineering·R J CohenT E Dushane
Feb 1, 1964·American Heart Journal·G K MOEJ A ABILDSKOV

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Citations

Jan 1, 1993·Annals of Biomedical Engineering·R A ProvinceN V Thakor
Oct 24, 1998·Progress in Biophysics and Molecular Biology·F J Vetter, A D McCulloch
Dec 1, 1991·Pacing and Clinical Electrophysiology : PACE·M Malik, A J Camm
May 1, 2015·Biomedical Engineering Online·Alejandro Lopez-PerezJose M Ferrero
Oct 29, 1998·Computers and Biomedical Research, an International Journal·P SiregarP Le Beux
Oct 1, 1995·IEEE Transactions on Bio-medical Engineering·M B WagnerM D Lesh
Aug 1, 1994·IEEE Transactions on Bio-medical Engineering·J M Rogers, A D McCulloch
Jun 26, 2020·Medical & Biological Engineering & Computing·Insha Majeed Wani, Sakshi Arora

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