Abstract
A prospective phase I-II study was conducted to determine the tolerance and local control rate of three-dimensional conformal radiotherapy (3-DCRT) for esophageal squamous cell carcinoma (SCC). Thirty patients underwent 3-DCRT for thoracic esophageal SCC. PTV1 composed of a 1.2-1.5 cm margin lateral around GTV and 3.0 cm margin superior/inferior of GTV. PTV2 encompassed GTV with a margin of 0.5-0.7 cm. The dose for PTV1 was 50 Gy in 2 Gy daily fractions; PTV2 received a boost of 16 Gy in 2 Gy daily fractions to a total dose of 66 Gy. Median follow-up time was 18 months. The most common acute toxicity was esophagitis in 63% of patients with RTOG grades 1-2, and in 3% with grade 3. RTOG grades 1-2 radiation pneumonitis developed in 27% of patients. One patient developed pulmonary fibrosis RTOG grade 2 and another patient experienced grade 3 pulmonary fibrosis. Two patients developed mild esophageal stricture requiring dilatation. Two-year overall survival, local disease progression-free rate, and distant metastasis-free rate were 69%, 36% and 56%, respectively. Although 3-DCRT to 66 Gy for esophageal SCC was well tolerated, the local control was disappointing. The result supports the use of chemoradiation as the standard care for...Continue Reading
References
Jun 11, 1992·The New England Journal of Medicine·A HerskovicB Emami
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L R CoiaG E Hanks
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Jul 15, 1990·Cancer·J F SeitzY Carcassonne
Feb 1, 1980·The British Journal of Radiology·L J Peters, H R Withers
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·T J SmithB Sischy
Jun 22, 1999·Cancer·L R CoiaG E Hanks
Jun 8, 2001·Cancer·E AnconaA Peracchia
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RetsasK MacRae
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Kai-Liang WuShen Zhao
May 26, 2004·Cancer·Jaffer A AjaniJack A Roth
Jul 9, 2004·The British Journal of Radiology·V W C WuD L W Kwong
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Kuai-Le ZhaoYang Wang
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Zhen ZhangRitsuko Komaki
Mar 21, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Trevor LeongRodney J Hicks
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Xian-Shu GaoJoe Y Chang
Mar 3, 2007·The Lancet Oncology·Val GebskiUNKNOWN Australasian Gastro-Intestinal Trials Group
Jun 5, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Zhongxing LiaoRitsuko Komaki
Citations
Jan 21, 2014·Radiation Oncology·Dai-yuan MaYou Lu
Oct 22, 2013·Radiation Oncology·Yong BaoHui Liu
Sep 19, 2012·Journal of Radiation Research·Qiang LinJunichi Asaumi
Nov 27, 2014·Radiation Oncology·Peng ZhangMeng-Zhong Liu
May 31, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hui LiuTiehua Rong
Nov 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jian ZhuRenaud De Crevoisier
Mar 19, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mao-Bin MengWang Ping
Sep 13, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nam P NguyenLexie Smith-Raymond
Jan 17, 2019·Thoracic Cancer·Xing-Wen FanKai-Liang Wu
Feb 27, 2020·Cancer Medicine·Xing-Wen FanKai-Liang Wu
Jan 18, 2013·Cell Biochemistry and Biophysics·Yipeng SongShiguan Zhu
May 6, 2021·Thoracic Cancer·Chen LiZefen Xiao
Apr 25, 2021·The Oncologist·Wencheng ZhangQingsong Pang