Three-dimensional dose comparison of flattening filter (FF) and flattening filter-free (FFF) radiation therapy by using NIPAM gel dosimetry

PloS One
Chun-Hsu YaoYuan-Jen Chang

Abstract

Intensity-modulated radiotherapy and volumetric modulated arc therapy are modern radiation therapy technologies that can create the desired dose distribution by multileaf collimator movement and dose-rate control. However, the homogeneous dose delivery of small-field irradiation techniques shows disagreement with that of treatment planning system. The removal of the flattening filter by flattening filter free (FFF) beam irradiation increases dose conformity and further reduces treatment delivery time in radiosurgery. This study aims to investigate the dose distribution of FFF and flattened beams for small-field irradiation by using the 3D gel dosimeter. The N-isopropylacrylamide (NIPAM) polymer gel dosimeter was employed to record the 3D dose distribution. In addition, flattened and FFF beams were compared using the gamma evaluation technique. The use of an FFF accelerator resulted in excellent radiation treatments with short delivery times and low doses to normal tissues and organs. Results also showed that the passing rate increased with the decrease of field size (30 × 30, 20 × 20, and 10 × 10 mm2) at post-irradiation times of 24, 48, 72, and 96 h. The passing rates for each field size were retained at the same level when ga...Continue Reading

References

Jun 3, 1998·Medical Physics·D A LowJ A Purdy
Oct 8, 2003·Medical Physics·Daniel A Low, James F Dempsey
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Yasushi NagataMasahiro Hiraoka
Mar 23, 2006·Physics in Medicine and Biology·Oleg N VassilievMichael T Gillin
May 3, 2007·Physics in Medicine and Biology·Y De DeeneS Visalatchi
Mar 28, 2008·Physics in Medicine and Biology·Jason Cashmore
Sep 25, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·G Massillon-JLS Robertson
May 28, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas PeguretWilko F A R Verbakel
Jun 4, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierina NavarriaMarta Scorsetti
Nov 16, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Florian StielerFrank Lohr
Nov 22, 2013·Journal of Applied Clinical Medical Physics·David B WiantBenjamin J Sintay
Dec 15, 2015·Physics in Medicine and Biology·Ciara M McErleanSimon J Doran
Oct 19, 2016·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Sara BarbieroMichele Avanzo
Oct 30, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Lalit KumarManoj Pal

❮ Previous
Next ❯

Citations

Jun 20, 2021·Critical Reviews in Oncology/hematology·Diana M Ghemiş, Loredana G Marcu
Jul 3, 2021·Gels·Maurizio Marrale, Francesco d'Errico

❮ Previous
Next ❯

Software Mentioned

MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.