Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

NMR in Biomedicine
Claudia CalcagnoZahi A Fayad

Abstract

Atherosclerotic plaques that cause stroke and myocardial infarction are characterized by increased microvascular permeability and inflammation. Dynamic contrast-enhanced MRI (DCE-MRI) has been proposed as a method to quantify vessel wall microvascular permeability in vivo. Until now, most DCE-MRI studies of atherosclerosis have been limited to two-dimensional (2D) multi-slice imaging. Although providing the high spatial resolution required to image the arterial vessel wall, these approaches do not allow the quantification of plaque permeability with extensive anatomical coverage, an essential feature when imaging heterogeneous diseases, such as atherosclerosis. To our knowledge, we present the first systematic evaluation of three-dimensional (3D), high-resolution, DCE-MRI for the extensive quantification of plaque permeability along an entire vascular bed, with validation in atherosclerotic rabbits. We compare two acquisitions: 3D turbo field echo (TFE) with motion-sensitized-driven equilibrium (MSDE) preparation and 3D turbo spin echo (TSE). We find 3D TFE DCE-MRI to be superior to 3D TSE DCE-MRI in terms of temporal stability metrics. Both sequences show good intra- and inter-observer reliability, and significant correlation ...Continue Reading

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Citations

Apr 27, 2016·Current Atherosclerosis Reports·Raf H M van HoofM Eline Kooi
Dec 13, 2016·Circulation. Cardiovascular Imaging·Claudia Calcagno, Zahi A Fayad
Oct 29, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nan WangDebiao Li
Aug 16, 2017·Magma·Bram F CoolenAart J Nederveen
Jul 30, 2016·Current Opinion in Lipidology·Margreet R de Vries, Paul H A Quax
Mar 7, 2021·Biomedicines·Kristina AndelovicAlma Zernecke
Jul 30, 2021·Frontiers in Neuroscience·Anni CopelandJetro J Tuulari

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