Three-dimensional echocardiography in the diagnosis of myocardial infarction and its correlation with the expressions of serum HIF-1α, HO-1 and VEGF

European Review for Medical and Pharmacological Sciences
Q YuN Zhao

Abstract

To investigate the correlation between three-dimensional echocardiography and the expressions of hypoxia-inducible factor-1 alpha (HIF-1α), heme oxygenase 1 (HO-1) and vascular endothelial growth factor (VEGF) in patients with myocardial infarction. A total of 40 patients with acute myocardial infarction treated with three-dimensional echocardiography and 40 patients receiving normal physical examination were selected. According to whether the disease occurred, they were divided into the myocardial infarction group and the normal group. Relevant indexes of two-dimensional and three-dimensional echocardiography and the expressions of HO-1, HIF-1α and VEGF in the myocardial infarction group and the normal group were compared. Besides, the correlation of the left ventricular ejection fraction (LVEF) measured by three-dimensional echocardiography with HIF-1α area, HO-1 area and VEGF area was analyzed. The left ventricular end-diastolic diameter (LVEDD) in the myocardial infarction group was significantly larger than that in the normal group (p<0.05), while the left ventricular inferior wall thickness (LVIWT) and LVEF in the myocardial infarction group were significantly smaller than those in the normal group (p<0.05). The global en...Continue Reading

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