Three-dimensional evaluation of postural stability in Parkinson's disease with mobile technology

NeuroRehabilitation
Sarah J OzingaJay L Alberts

Abstract

Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions. Twenty-seven individuals with Parkinson's disease and 27 age-matched controls completed various balance tasks. A postural stability metric quantifying the amplitude (peak-to-peak) of sway acceleration in each movement direction was compared between groups. The peak-to-peak value in each direction for each individual with Parkinson's disease across all trials was expressed as a normalized value of the control data to identify individuals with severe postural instability, termed Cleveland Clinic-Postural Stability Index. In all conditions, the balance metric for peak-to-peak was significantly greater in Parkinson's disease compared to controls (p <...Continue Reading

References

Aug 1, 1992·Journal of the Neurological Sciences·F B HorakL M Nashner
Jun 1, 1996·Journal of Neurophysiology·D A WinterK F Zabjek
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·B R BloemR A Roos
Apr 28, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L A BrownM H Woollacott
Dec 31, 2004·American Journal of Physical Medicine & Rehabilitation·Mallikarjuna NallegowdaMadhuri Behari
Nov 10, 2005·Gait & Posture·A L AdkinJ H J Allum
Jul 5, 2007·Experimental Brain Research·J W BłaszczykG Opala
Jun 4, 2008·Neurology·D MuslimovicUNKNOWN CARPA Study Group
Jul 23, 2008·Journal of Neurologic Physical Therapy : JNPT·Merrill R LandersPeter Altenburger
Sep 16, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jasper E VisserBastiaan R Bloem
Oct 31, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anna FrenklachHelen Bronte-Stewart
Mar 3, 2009·Age and Ageing·Maura O'SullivanCiarán Finucane
Jul 30, 2011·Exercise and Sport Sciences Reviews·Jay L AlbertsMicheal Phillips
Feb 10, 2012·The New England Journal of Medicine·Fuzhong LiSara S Batya
Aug 24, 2012·Journal of Neuroengineering and Rehabilitation·Martina ManciniFay B Horak
Aug 9, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Bernadette SchoneburgJohn G Nutt
Aug 26, 2014·Experimental Brain Research·Sarah J Ozinga, Jay L Alberts
Mar 27, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah J OzingaJay L Alberts
Apr 7, 2015·Journal of Athletic Training·Jay L AlbertsAnil K Thota
Sep 18, 2015·Medicine and Science in Sports and Exercise·Jay L AlbertsSusan M Linder

❮ Previous
Next ❯

Citations

May 26, 2018·Medicine and Science in Sports and Exercise·Susan M LinderJay L Alberts
Mar 23, 2019·Military Medicine·Susan M LinderJay L Alberts
Apr 12, 2019·Biomolecules·Fabio Del BelloWilma Quaglia
May 7, 2019·Frontiers in Human Neuroscience·Kelly J FellerFay B Horak
May 8, 2019·Parkinson's Disease·Andres Maldonado-NaranjoAndre Machado
Nov 12, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Richard RammoAndre Machado
Jan 16, 2020·Ophthalmology Retina·Aleksandra RachitskayaJay Alberts
Apr 26, 2021·Parkinsonism & Related Disorders·Sarah J OzingaJay L Alberts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Sarah J OzingaJay L Alberts
The International Journal of Neuroscience
Antonis P StylianouCarl W Luchies
Medicine and Science in Sports and Exercise
Jay L AlbertsSusan M Linder
Movement Disorders : Official Journal of the Movement Disorder Society
Bart P C Van de WarrenburgJ H J Allum
© 2022 Meta ULC. All rights reserved