Three dimensional fusion of electromechanical mapping and magnetic resonance imaging for real-time navigation of intramyocardial cell injections in a porcine model of chronic myocardial infarction

The International Journal of Cardiovascular Imaging
F J van SlochterenS A J Chamuleau

Abstract

For cardiac regenerative therapy intramyocardial catheter guided cell transplantations are targeted to the infarct border zone (IBZ) i.e. the closest region of viable myocardium in the vicinity of the infarct area. For optimal therapeutic effect this area should be accurately identified. However late gadolinium enhanced magnetic resonance imaging (LGE-MRI) is the gold standard technique to determine the infarct size and location, electromechanical mapping (EMM) is used to guide percutaneous intramyocardial injections to the IBZ. Since EMM has a low spatial resolution, we aim to develop a practical and accurate technique to fuse EMM with LGE-MRI to guide intramyocardial injections. LGE-MRI and EMM were obtained in 17 pigs with chronic myocardial infarction created by balloon occlusion of LCX and LAD coronary arteries. LGE-MRI and EMM datasets were registered using our in-house developed 3D CartBox image registration software toolbox to assess: (1) the feasibility of the 3D CartBox toolbox, (2) the EMM values measured in the areas with a distinct infarct transmurality (IT), and (3) the highest sensitivity and specificity of the EMM to assess IT and define the IBZ. Registration of LGE-MRI and EMM resulted in a mean error of 3.01 ±...Continue Reading

References

Apr 5, 2001·Nature·D OrlicP Anversa
May 10, 2001·Journal of the American College of Cardiology·T WolfS A Ben-Haim
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Dec 21, 2004·Journal of the American College of Cardiology·Luciano C AmadoJoão A C Lima
Jul 12, 2005·Annual Review of Biomedical Engineering·Jeffrey W HolmesJames W Covell
Nov 5, 2005·Scandinavian Cardiovascular Journal : SCJ·Einar HeibergHåkan Arheden
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Gregory M Fomovsky, Jeffrey W Holmes
Mar 1, 2009·Journal of Cardiovascular Translational Research·Peter J Psaltis, Stephen G Worthley
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nilesh R GhugreGraham A Wright
May 19, 2011·Nature Reviews. Cardiology·Mariann Gyöngyösi, Nabil Dib
Apr 12, 2013·European Heart Journal Cardiovascular Imaging·Jorge RomeroMario J Garcia
Oct 22, 2014·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·F J van SlochterenS A J Chamuleau

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Citations

Feb 3, 2018·Journal of Cardiovascular Translational Research·Wouter A GathierSteven A J Chamuleau
Jan 29, 2019·The International Journal of Cardiovascular Imaging·René van EsFrebus J van Slochteren
Feb 23, 2019·European Journal of Heart Failure·Christina PaitazoglouUNKNOWN SCIENCE Investigators
Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Marijn M C PetersKlaus Neef
Mar 21, 2017·The International Journal of Cardiovascular Imaging·Johan H C ReiberNico R L Vande Veire
Jul 25, 2019·Journal of Cardiovascular Translational Research·Hans Thijs van den BroekRené van Es

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Methods Mentioned

BETA
imaging technique

Software Mentioned

NOGA ® XP
- MRI
LGE
CARTO
NOGA
Matlab
EMM
SPSS Statistics
3D
CartBox

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