Three-dimensional gait biomechanics in Parkinson's disease: evidence for a centrally mediated amplitude regulation disorder

Movement Disorders : Official Journal of the Movement Disorder Society
Meg E MorrisF Huxham

Abstract

We examined whether people with Parkinson's disease (PD) have a central amplitude regulation disorder using three-dimensional (3-D) gait analyses to compare the effects of medication and attentional strategies on gait in 12 PD subjects and 12 matched comparison subjects. Subjects with PD first performed several 10-m gait trials at preferred speed while off levodopa. They then walked at preferred speed on levodopa; off levodopa with cues; and on levodopa with cues. Control subjects walked at preferred speed and then with visual cues to match their stride length to PD values. As well as spatiotemporal footstep data, pelvic and lower limb kinematic profiles and angle-angle diagrams were produced for sagittal, coronal, and transverse plane movements using a 3-D motion analysis system. In people with PD, decreased step length was accompanied by reduced movement amplitude across all lower limb joints, in all movement planes. When control subjects were required to walk with short steps matched to the size of PD comparisons, they displayed a similar multijoint reduction in amplitude. For PD subjects, both levodopa and visual cues increased movement amplitude across all lower limb joints. Amplitude increased further when levodopa and vi...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Aug 1, 1991·Brain : a Journal of Neurology·P BrotchieM K Horne
Aug 1, 1990·Journal of the Neurological Sciences·O BlinG Serratrice
Mar 1, 1987·Electroencephalography and Clinical Neurophysiology·J P DickC D Marsden
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·C D Marsden
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
May 1, 1985·Journal of the Neurological Sciences·J P Lakke
Jan 1, 1972·Brain : a Journal of Neurology·E Knutsson
Apr 1, 1983·Acta Orthopaedica Scandinavica·I Bjerkreim, C Hellum
May 1, 1995·Annals of Neurology·V DietzL Baumgartner
Dec 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·M E MorrisJ J Summers
Aug 1, 1994·Brain : a Journal of Neurology·C D Marsden, J A Obeso
Oct 1, 1994·Brain : a Journal of Neurology·M E MorrisJ J Summers
Apr 1, 1996·Brain : a Journal of Neurology·M E MorrisJ J Summers
Sep 1, 1996·Archives of Neurology·L DefebvreA Destée
Dec 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·M J SteigerC D Marsden
Dec 1, 1996·Current Opinion in Neurobiology·T Wichmann, M R DeLong
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·M MorrisJ Summers
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J M HausdorffA L Goldberger
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J D O'SullivanA J Hughes
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·R CunningtonJ L Bradshaw
Mar 2, 1999·Brain : a Journal of Neurology·J P AzulayJ Pouget
Sep 27, 2000·Brain : a Journal of Neurology·G N LewisS E Walt
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H StolzeG Deuschl
Mar 17, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D E ShanS I Yeh
Nov 1, 1954·A.M.A. Archives of Neurology and Psychiatry·R S SCHWABS WALKER

❮ Previous
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Citations

Jan 25, 2008·Experimental Brain Research·Pablo Arias, Javier Cudeiro
Oct 9, 2008·Experimental Brain Research·Darren R HockingJohn L Bradshaw
Apr 3, 2007·Journal of Neurology·Nieuwboer AliceDesloovere Kaat
Mar 24, 2006·European Child & Adolescent Psychiatry·Nicole J RinehartJenny McGinley
Feb 26, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro PicelliNicola Smania
Apr 13, 2010·Neuropsychology Review·Alice Cronin-Golomb
Jun 19, 2010·Current Neurology and Neuroscience Reports·Nina Browner, Nir Giladi
Mar 30, 2012·Journal of Motor Behavior·Manuela GalliGiorgio Albertini
Oct 30, 2008·Brain : a Journal of Neurology·Sigurros DavidsdottirAlice Cronin-Golomb
May 13, 2009·Brain : a Journal of Neurology·Rachel CheeRobert Iansek
Apr 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Geraldine E MannPaul N Taylor
Jan 1, 2010·Journal of Neurophysiology·Catherine ChoTheodore Raphan
Nov 5, 2008·Neurorehabilitation and Neural Repair·Minna HongGammon M Earhart
Jul 31, 2014·Journal of Communication Disorders·Jason A Whitfield, Alexander M Goberman
Jan 9, 2013·Journal of Bodywork and Movement Therapies·Danielli Souza SpecialiPaulo Roberto Garcia Lucareli
Dec 25, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Valeria AgostiGiuseppe Sorrentino
Nov 18, 2008·Gait & Posture·Jennifer L McGinleyMeg E Morris
Jan 1, 2014·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Sunee BovonsunthonchaiVimonwan Hiengkaew
Dec 27, 2012·IEEE Transactions on Bio-medical Engineering·Benoit MarianiKamiar Aminian
Jan 18, 2008·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ilaria CarpinellaMaurizio Ferrarin
Sep 2, 2015·Vision Research·Xiaolin RenAlice Cronin-Golomb
Jan 26, 2013·Gait & Posture·Rodrigo VitórioLilian Teresa Bucken Gobbi
Apr 21, 2016·Journal of Neuroengineering and Rehabilitation·Sabato MelloneLorenzo Chiari
Mar 29, 2014·Frontiers in Human Neuroscience·Lea Awai, Armin Curt
Aug 2, 2016·Expert Review of Neurotherapeutics·Antonio SuppaGiovanni Fabbrini
Jun 2, 2006·Gait & Posture·Meg E MorrisGregory W Dalton
Dec 17, 2009·Parkinsonism & Related Disorders·D CameronR Iansek
Apr 15, 2017·PloS One·Björn MüllerNicolas Ludolph
Apr 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Lynn RochesterDavid Burn
Jul 8, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Anna CastagnaAlberto Albanese
Nov 6, 2009·Archives of Physical Medicine and Rehabilitation·Martin SvehlíkChristian Enzinger
Dec 21, 2016·Archives of Physical Medicine and Rehabilitation·Michael H ColePeter A Silburn
Jun 30, 2016·Neurorehabilitation and Neural Repair·Michael H ColePeter A Silburn

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