Three-dimensional genome: developmental technologies and applications in precision medicine.

Journal of Human Genetics
Yingqi LiXiao Zhu

Abstract

In the 20th century, our familiar structure of DNA was the double helix. Due to technical limitations, we do not have a good way to understand the finer structure of the genome, let alone its transcriptional regulation. Until the advent of 3C technologies, we were no longer blind to this one. Three-dimensional (3D) genomics is a new subject, which mainly studies the 3D structure and transcriptional regulation of eukaryotic genomes. Now, this field mainly has Hi-C series and CHIA-PET series technologies. Through 3D genomics, we can understand the basic structure of DNA, understand the growth and development of organisms and the occurrence of diseases, so as to promote human medical and health undertakings. The review introduces the main research techniques of 3D genomics and their characteristics, the latest development of 3D genome structure, the relationship between diseases and 3D genome structure, the applications of 3D genome in precision medicine, and the development of the 4D nucleome project.

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Citations

Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhen LiuYi Qi
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yanan LiuYi Qi
Nov 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuHui Luo
Mar 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shimin XieXiao Zhu
Sep 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Danqi YaoXiao Zhu
Aug 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peijia XuXiao Zhu
Sep 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yujia ZhouXiao Zhu
Jun 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chang SongXiao Zhu
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shang LiXiao Zhu
Jul 6, 2021·Current Genomics·Ivan Y IourovYuri B Yurov

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Methods Mentioned

BETA
imaging techniques
Hi-C
DLO Hi-C
single-cell Hi-C
immunoprecipitation
PCR
DLO
PLAC-seq
genotyping
single-cell

Software Mentioned

Hi
ORCA
HiChIP
CRISPR
ChromEMT
ChIA
Capture C
Sirius
MERFISH
CESAM

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