Three-dimensional high-frequency characterization of cancerous lymph nodes.

Ultrasound in Medicine & Biology
Jonathan MamouErnest J Feleppa

Abstract

High-frequency ultrasound (HFU) offers a means of investigating biologic tissue at the microscopic level. High-frequency, three-dimensional (3-D) quantitative-ultrasound (QUS) methods were developed to characterize freshly-dissected lymph nodes of cancer patients. Three-dimensional ultrasound data were acquired from lymph nodes using a 25.6-MHz center-frequency transducer. Each node was inked prior to tissue fixation to recover orientation after sectioning for 3-D histologic evaluation. Backscattered echo signals were processed using 3-D cylindrical regions-of-interest to yield four QUS estimates associated with tissue microstructure (i.e., effective scatterer size, acoustic concentration, intercept and slope). QUS estimates were computed following established methods using two scattering models. In this study, 46 lymph nodes acquired from 27 patients diagnosed with colon cancer were processed. Results revealed that fully-metastatic nodes could be perfectly differentiated from cancer-free nodes using slope or scatterer-size estimates. Specifically, results indicated that metastatic nodes had an average effective scatterer size (i.e., 37.1 +/- 1.7 microm) significantly larger (p < 0.05) than that in cancer-free nodes (i.e., 26 +...Continue Reading

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Citations

Dec 13, 2012·The Journal of the Acoustical Society of America·Emilie Franceschini, Régine Guillermin
Aug 10, 2013·The Journal of the Acoustical Society of America·Jeremy P KemmererMichael L Oelze
Jun 12, 2014·The Journal of the Acoustical Society of America·Emilie FranceschiniJean-François Landrier
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Jan 22, 2013·The Journal of Surgical Research·Emi Saegusa-BeecroftErnest J Feleppa
Feb 15, 2011·Ultrasound in Medicine & Biology·Jonathan MamouErnest J Feleppa
Apr 6, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emilie FranceschiniJonathan Mamou
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Sep 18, 2018·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Daniel Rohrbach, Jonathan Mamou
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Apr 27, 2019·Ultrasound in Medicine & Biology·Emilie FranceschiniBenjamin Guillet
Mar 3, 2011·Seminars in Oncology·Ernest J FeleppaJunji Machi

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