Three-dimensional macronutrient-associated Fos expression patterns in the mouse brainstem.

PloS One
Jessica SchwarzNicolas Darcel

Abstract

The caudal brainstem plays an important role in short-term satiation and in the control of meal termination. Meal-related stimuli sensed by the gastrointestinal (GI) tract are transmitted to the area postrema (AP) via the bloodstream, or to the nucleus tractus solitarii (NTS) via the vagus nerve. Little is known about the encoding of macronutrient-specific signals in the caudal brainstem. We hypothesized that sucrose and casein peptone activate spatially distinct sub-populations of NTS neurons and thus characterized the latter using statistical three-dimensional modeling. Using immunolabeling of the proto-oncogene Fos as a marker of neuronal activity, in combination with a statistical three-dimensional modeling approach, we have shown that NTS neurons activated by sucrose or peptone gavage occupy distinct, although partially overlapping, positions. Specifically, when compared to their homologues in peptone-treated mice, three-dimensional models calculated from neuronal density maps following sucrose gavage showed that Fos-positive neurons occupy a more lateral position at the rostral end of the NTS, and a more dorsal position at the caudal end. To our knowledge, this is the first time that subpopulations of NTS neurons have be ...Continue Reading

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Mar 22, 2014·Physiology & Behavior·Guillaume de Lartigue
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher D MorrisonTara M Henagan
Feb 8, 2014·PloS One·Jasmine Burguet, Philippe Andrey
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Oct 15, 2020·The Proceedings of the Nutrition Society·Daniel ToméDalila Azzout-Marniche
Nov 16, 2019·Journal of Agricultural and Food Chemistry·Daniel ToméDalila Azzout-Marniche

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