Three-dimensional numerical simulation of blood flow in the aortic arch during cardiopulmonary bypass

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Yoshiyuki TokudaShigeru Maruyama

Abstract

To better understand the mechanism of stroke during cardiopulmonary bypass, it is necessary to obtain information on the location of turbulence, wall pressure, and flow distribution within the aortic arch. Blood flow was numerically simulated using the finite element method in the following representative case: a curved arterial cannula was inserted into the anterior wall of the distal ascending aorta 2 cm below the orifice of brachiocephalic artery. Perfusion was performed, with a bypass flow index of 2.5l min(-1) m(-2). Computational grids, consisting of 1,493,297 tetrahedral elements, were generated. The highest wall pressure (3104.8 Pa) was observed at the superior-posterior wall of the aorta below the orifice of the brachiocephalic artery where jet flow impingement occurred. The maximum wall shear stress was 25.1 Pa. High velocity vortex started below the orifice of the brachiocephalic artery. The turbulent flows continued along the posterior wall and then mainly flowed off into the left subclavian artery. Therefore, in the present case, an embolic event in the territory of the left subclavian artery could occur if a plaque was present at the superior-posterior wall of the aorta below the orifice of the brachiocephalic art...Continue Reading

Citations

Dec 1, 2012·Journal of Biomechanics·Prahlad G MenonKerem Pekkan
Dec 22, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Andres F OsorioWilliam M DeCampli
Sep 10, 2014·Clinical Implant Dentistry and Related Research·Chandur WadhwaniKwok-Hung Chung
Oct 21, 2011·Biotechnology and Bioengineering·Amlan ChakrabortyR Eric Berson
Feb 19, 2014·Artificial Organs·Tim A S KaufmannUlrich Steinseifer
Sep 23, 2014·Artificial Organs·Tim A S KaufmannUlrich Steinseifer
Jan 28, 2010·The Annals of Thoracic Surgery·Koji YamanaSatoshi Hoshino
Apr 25, 2015·Journal of Biomechanics·Martin BüsenSimon J Sonntag
Mar 31, 2015·The Journal of Thoracic and Cardiovascular Surgery·Khalil MasabniJ F Sabik
Nov 1, 2011·Journal of Biomechanics·Alexander AssmannArtur Lichtenberg
Aug 21, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Michalis XenosDanny Bluestein
Jul 13, 2014·Annals of Biomedical Engineering·Michael NeidlinTim A S Kaufmann
May 23, 2019·Journal of Biomechanical Engineering·Fiona MaloneLiam Morris
Jul 9, 2020·International Journal for Numerical Methods in Biomedical Engineering·Gaizka LoroñoRafael Cisneros
Mar 23, 2017·Physiological Reports·Ran Arieli, Abraham Marmur
May 29, 2019·Stroke; a Journal of Cerebral Circulation·Fiona MaloneLiam Morris
Mar 23, 2011·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Sebastian StühleWojciech Kowalczyk
May 31, 2018·Biomedical Engineering Online·Sudharsan Madhavan, Erica M Cherry Kemmerling

Related Concepts

Descending Aorta
Cardiopulmonary Bypass
In Silico
Hemodynamics
Diagnostic Radiologic Examination
Stress, Mechanical
Benefit-Risk Assessment
Acute Cerebrovascular Accidents
Imaging, Three-Dimensional, Computer Assisted

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