Three-dimensional object-oriented modeling of the stomach for the purpose of microprocessor-controlled functional stimulation

IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society
Peter Z RashevMartin P Mintchev

Abstract

Three-dimensional (3-D) object-oriented models are needed for optimizing gastric electrical stimulation by performing virtual computer experiments. The aim of the study was to create a 3-D object-oriented electromechanical model of the stomach in vivo for the purpose of microprocessor controlled functional stimulation. The stomach was modeled using coaxial truncated conoids as objects. The strength of an external stimulating electric field generated by circumferentially implanted wire electrodes is related to artificial neurogenic and myogenic control of smooth muscle depolarization and contraction. Variation of the field strength modulates the frequency and concentration of acetylcholine release, as well as the transmembrane voltage of the muscle cells. Mechanical response of the stimulated tissue was quantified by two parametric functions of the electric field strength representing the relative contractile force and geometrical displacement of the gastric surface. Data from previously conducted canine experiments were used to test the validity of the model. The model was applied to simulate contractions with different positions, orientation and number of the circumferentially implanted stimulating electrodes. The model combin...Continue Reading

References

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Oct 12, 2000·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·P Z RashevK L Bowes

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Citations

May 5, 2005·Annals of Biomedical Engineering·Babajide O FamiloniGuy Voeller
Mar 16, 2007·IEEE Transactions on Bio-medical Engineering·Denis OnenMartin P Mintchev
May 6, 2006·Medical Engineering & Physics·Ehsan JalilianMartin P Mintchev
Dec 20, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrei Irimia, L Alan Bradshaw
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrei Irimia, L Alan Bradshaw
Sep 9, 2005·Physics in Medicine and Biology·Andrei Irimia, L Alan Bradshaw
Jul 20, 2006·Digestive Diseases·Hubert Monnikes, Ivo R van der Voort
May 11, 2021·Frontiers in Neuroscience·Leo K ChengNiranchan Paskaranandavadivel

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