Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine

Nano Letters
Shixuan ChenJingwei Xie

Abstract

Assembling electrospun nanofibers with controlled alignment into three-dimensional (3D), complex, and predesigned shapes has proven to be a difficult task for regenerative medicine. Herein, we report a novel approach inspired by solids of revolution that transforms two-dimensional (2D) nanofiber mats of a controlled thickness into once-inaccessible 3D objects with predesigned shapes. The 3D objects are highly porous, consisting of layers of aligned nanofibers separated by gaps ranging from several micrometers to several millimeters. Upon compression, the objects are able to recover their original shapes. The porous objects can serve as scaffolds, guiding the organization of cells and producing highly ordered 3D tissue constructs. Additionally, subcutaneous implantation in rats demonstrates that the 3D objects enable rapid cell penetration, new blood vessel formation, and collagen matrix deposition. This new class of 3D hierarchical nanofiber architectures offers promising advancements in both in vitro engineering of complex 3D tissue constructs/models or organs and in vivo tissue repair and regeneration.

References

Nov 21, 2000·Scandinavian Journal of Medicine & Science in Sports·P Kannus
Nov 19, 2005·Science·Molly M Stevens, Julian H George
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Rafael Grytz, Günther Meschke
Jul 22, 2010·Nanoscale·Jingwei XieYounan Xia
Nov 19, 2011·Advanced Materials·Toby D BrownDietmar W Hutmacher
Mar 16, 2013·Biomaterials·Karl E KadorJeffrey L Goldberg
Jan 30, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Minhee Lee, Ho-Young Kim
Oct 9, 2014·Calcified Tissue International·Walter R Frontera, Julien Ochala
Sep 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yihui ZhangJohn A Rogers
Jul 12, 2016·Journal of Nanoscience and Nanotechnology·Aleksander GóraSeeram Ramakrishna
Oct 7, 2016·Advanced Healthcare Materials·Jiang JiangJingwei Xie
May 8, 2018·Advanced Drug Delivery Reviews·Shixuan ChenJingwei Xie
Dec 14, 2018·Bio-design and Manufacturing·Ian HollandWenmiao Shu
Apr 25, 2019·Nature Biomedical Engineering·Luke A MacQueenKevin Kit Parker

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Citations

Jan 31, 2020·Advanced Healthcare Materials·Tong WuYounan Xia
Jun 14, 2020·Journal of Functional Biomaterials·Giuseppe ArrabitoBruno Pignataro
Mar 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shixuan ChenJingwei Xie
May 1, 2021·ACS Biomaterials Science & Engineering·Shixuan ChenJingwei Xie

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