Three-dimensional printed millifluidic devices for zebrafish embryo tests

Biomicrofluidics
Feng ZhuDonald Wlodkowic

Abstract

Implementations of Lab-on-a-Chip technologies for in-situ analysis of small model organisms and embryos (both invertebrate and vertebrate) are attracting an increasing interest. A significant hurdle to widespread applications of microfluidic and millifluidic devices for in-situ analysis of small model organisms is the access to expensive clean room facilities and complex microfabrication technologies. Furthermore, these resources require significant investments and engineering know-how. For example, poly(dimethylsiloxane) soft lithography is still largely unattainable to the gross majority of biomedical laboratories willing to pursue development of chip-based platforms. They often turn instead to readily available but inferior classical solutions. We refer to this phenomenon as workshop-to-bench gap of bioengineering science. To tackle the above issues, we examined the capabilities of commercially available Multi-Jet Modelling (MJM) and Stereolithography (SLA) systems for low volume fabrication of optical-grade millifluidic devices designed for culture and biotests performed on millimetre-sized specimens such as zebrafish embryos. The selected 3D printing technologies spanned a range from affordable personal desktop systems to ...Continue Reading

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Citations

Mar 1, 2016·Lab on a Chip·Fan YangZuanguang Chen
Oct 14, 2016·Biomicrofluidics·Kimberly PlevniakMei He
Nov 26, 2016·Sensors·Mohammed-Baker HabhabJoe Fujiou Lo
Aug 14, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Rhys Cartlidge, Donald Wlodkowic
Mar 13, 2019·International Journal of Molecular Sciences·Carmen Mabel González-HenríquezJuan Rodríguez Hernandez
Oct 31, 2015·Scientific Reports·Krisna C BhargavaNoah Malmstadt
May 6, 2019·Advanced Healthcare Materials·Ashley L BeckwithJeffrey T Borenstein
Nov 7, 2019·Micromachines·Jia Ming ZhangHuiling Duan
Apr 30, 2019·Briefings in Functional Genomics·Arezoo Khalili, Pouya Rezai
Sep 28, 2017·Bioengineering·Hee-Gyeong YiDong-Woo Cho
Nov 15, 2018·Micromachines·Nurul Mohd FuadDonald Wlodkowic
Jan 17, 2017·Current Transplantation Reports·Ryan D SocholJoseph V Bonventre
Apr 4, 2021·Micromachines·Nafisat GyimahTamas Pardy

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