PMID: 11927007Apr 3, 2002Paper

Three-dimensional reconstruction and fractal geometric analysis of serrated adenoma

Japanese Journal of Cancer Research : Gann
Masahiro IwabuchiHironobu Sasano

Abstract

Serrated adenoma (SA) is a relatively newly defined entity of colorectal neoplasm first characterized by Longacre and Fenoglio-Preiser in 1990. This lesion is characterized by a complicated serrated edge of crypts. In this study, we performed three-dimensional (3-D) reconstruction, including 3-D distribution patterns of Ki-67-positive cells and fractal dimension of SA, in order to evaluate the nature of the complicated architecture, including its possible morphogenesis. We studied nine colonoscopic polypectomy specimens including three SAs, three tubular adenomas (TAs), and three hyperplastic polyps (HPs). Sixty serial tissue sections per case were stained alternately with hematoxylin and eosin (H&E) and Ki-67 immunostain. Each serial image was then digitized for 3-D computer analysis and the distribution pattern of Ki-67-positive cells was evaluated. Ki-67-immunostained sections were also subjected to 2-D quantitative morphometric study. In addition, the fractal dimensions of images from H&E-stained sections were examined using a box-counting method. Results of the 3-D reconstruction study demonstrated that glandular budding and branching were more frequent in SA than in TA or HP. These findings were confirmed quantitatively b...Continue Reading

References

Oct 1, 1979·The Tohoku Journal of Experimental Medicine·H WatanabeY Goto
Apr 1, 1992·The Journal of Pathology·S S Cross, D W Cotton
Dec 1, 1990·Histopathology·D C Brown, K C Gatter
Jun 1, 1990·The American Journal of Surgical Pathology·T A Longacre, C M Fenoglio-Preiser
Mar 1, 1986·Journal of Applied Physiology·B J WestA L Goldberger
Nov 1, 1968·Journal of Clinical Pathology·J F Arthur
Sep 1, 1995·The Journal of Pathology·M J VilelaS R Boschetti
Apr 1, 1994·The Journal of Pathology·S S CrossD W Cotton
Aug 1, 1993·The Journal of Pathology·S S CrossJ C Underwood
Apr 1, 1997·The American Journal of Surgical Pathology·M KangI Okayasu
May 26, 1998·Japanese Journal of Cancer Research : Gann·H UchidaS Baba
Jan 30, 1999·The Journal of Pathology·T HiyamaE Tahara

❮ Previous
Next ❯

Citations

Dec 29, 2007·The American Journal of Surgical Pathology·Emina Emilia TorlakovicDale C Snover
Dec 2, 2005·Current Opinion in Gastroenterology·Kristopher S Cunningham, Robert H Riddell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.