Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots

Scientific Reports
Yoshito HirataKazuyuki Aihara


Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information.


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Jun 8, 2018·The International Journal of Biostatistics·Nelle Varoquaux
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Datasets Mentioned


Methods Mentioned

single-cell Hi-C
single cell Hi-C.
single-cell Hi-C.

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