journal cover

Three-dimensional structures of membrane proteins from genomic sequencing

Cell

May 15, 2012

Thomas A HopfDebora S Marks

Abstract

We show that amino acid covariation in proteins, extracted from the evolutionary sequence record, can be used to fold transmembrane proteins. We use this technique to predict previously unknown 3D structures for 11 transmembrane proteins (with up to 14 helices) from their sequences alon...read more

Mentioned in this Paper

Symporters
Conserved Sequence
Cinchona pubescens
RHO gene
Molecular Helix
M Protein, multiple myeloma
Protein Family
Rhodopsin
Extracellular
G-Protein-Coupled Receptors
35
1
1
763
1
3
Paper Details
References
  • References62
  • Citations201
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  • References62
  • Citations201
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Three-dimensional structures of membrane proteins from genomic sequencing

Cell

May 15, 2012

Thomas A HopfDebora S Marks

PMID: 22579045

DOI: 10.1016/j.cell.2012.04.012

Abstract

We show that amino acid covariation in proteins, extracted from the evolutionary sequence record, can be used to fold transmembrane proteins. We use this technique to predict previously unknown 3D structures for 11 transmembrane proteins (with up to 14 helices) from their sequences alon...read more

Mentioned in this Paper

Symporters
Conserved Sequence
Cinchona pubescens
RHO gene
Molecular Helix
M Protein, multiple myeloma
Protein Family
Rhodopsin
Extracellular
G-Protein-Coupled Receptors
35
1
1
763
1
3

Similar Papers Found In These Feeds

Membrane Transport in Heart Failure

This feed focuses on Membrane Transport proteins and their dysfunction which can lead to heart disease. Discover the latest research on Membrane Transport in Heart Failure.

Valvular Heart Disease

Valvular heart disease causes significant burden within the realm of cardiovascular diseases and is increasing in prevalence, especially that of aortic valve insufficiency. Rheumatic fever causing valvular diseases has decreased incidence in industrialized countries. Discover the latest research on valvular disease here.

Related Papers

Nature Biotechnology

Protein structure prediction from sequence variation

Nature BiotechnologyNovember 10, 2012
Debora S MarksChris Sander
PloS One

Protein 3D structure computed from evolutionary sequence variation

PloS OneDecember 14, 2011
Debora S MarksChris Sander
Paper Details
References
  • References62
  • Citations201
12345...
  • References62
  • Citations201
12345...
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