PMID: 16633175Apr 25, 2006Paper

Three-dimensional technology and bone morphogenetic protein in frontal bone reconstruction

The Journal of Craniofacial Surgery
Claes ArnanderThomas Engstrand

Abstract

Osteoinductive bone morphogenetic proteins (BMPs) may be used in humans to facilitate healing of bony defects. The effect of different BMPs is, as with many other growth factors, highly dependent on the delivery vehicle. Bovine type I collagen is currently used in the clinical setting as a carrier and has been approved in several countries for human use. Here, we report the reconstruction of a frontal bone defect using heparin together with bovine type I collagen, hyaluronic acid, and fibrin as vehicles for BMP-2. A bony structure was created on the back of the patient by treating the latissimus dorsi muscle with the growth factor. A polyamide mold was used as a template to achieve the desired shape. The bone structure was transplanted into the defect site via microsurgical techniques. Although the prefabricated bone was not large enough tocover the entire frontal defect, the reconstruction was completed by using an additional cranial implant.

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Citations

Aug 9, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·James Tait GoodrichOren Tepper
Feb 24, 2011·Biotechnology Letters·Jin-Woo ParkChang-Hyeon An
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