Three-dimensional topography of corticopontine projections from rat sensorimotor cortex: comparisons with corticostriatal projections reveal diverse integrative organization

The Journal of Comparative Neurology
T B LeergaardJ G Bjaalie

Abstract

The major cortical-subcortical re-entrant pathways through the basal ganglia and cerebellum are considered to represent anatomically segregated channels for information originating in different cortical areas. A capacity for integrating unique combinations of cortical inputs has been well documented in the basal ganglia circuits but is largely undefined in the precerebellar circuits. To compare and quantify the amount of overlap that occurs in the first link of the cortico-ponto-cerebellar pathway, a dual tracing approach was used to map the spatial relationship between projections originating from the primary somatosensory cortex (SI), the secondary somatosensory cortex (SII), and the primary motor cortex (MI). The anterograde tracers biotinylated dextran amine and Fluoro-Ruby were injected into homologous whisker representations of either SI and SII, or SI and MI. The ensuing pontine labeling patterns were analyzed using a computerized three-dimensional reconstruction approach. The results demonstrate that whisker-related projections from SI and MI are largely segregated. At some locations, the two projections are adjoining and partly overlapping. Furthermore, SI contributes significantly more corticopontine projections than ...Continue Reading

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Citations

Aug 25, 2007·Brain Structure & Function·Ingeborg BolstadJan G Bjaalie
Jul 30, 2014·Nature Neuroscience·Rémi D ProvilleClément Léna
Aug 11, 2011·PloS One·Izabela M ZakiewiczJan G Bjaalie
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Jun 24, 2015·Neuropsychologia·Rochelle Ackerley, Anne Kavounoudias
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Jul 30, 2021·ELife·Jian-Zhong GuoAdam W Hantman
Jul 12, 2020·Neuroscience·Ayesha R ThanawallaEiman Azim

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