PMID: 9177951Jan 1, 1997Paper

Three-dimensional visualization and quantification of the benzodiazepine receptor population within a living human brain using PET and MRI

European Archives of Psychiatry and Clinical Neuroscience
S Pauli, G Sedvall

Abstract

Positron emission tomography (PET) in combination with receptor-selective high-affinity radioligands allows the characterization of neuroreceptor distributions in the living human brain. Thus far, the visualization and quantification of receptors with PET have been limited to series of two-dimensional (2D) image planes of the anatomic receptor distribution. The development of high-resolution PET has increased the number of planes to approximately 50, supplying an excessive amount of image information from a single experiment. The inherent limitations of 2D techniques make them insufficient to apprehend and efficiently analyze this cumbersome amount of data. In the present communication we describe procedures to visualize and quantify in three dimensions (3D) the total image information from the compound set of 47 2D planes of a PET experiment using commercially available software. Three-dimensional computer graphic and volume rendering techniques were used to analyze and display the results. For the experimental application the benzodiazepine (BZ) antagonist [11C]flumazenil was used as radioligand to visualize the BZ receptor (BZR) population in the brain of a healthy human subject. Three-dimensional images of the radioligand b...Continue Reading

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Citations

Mar 4, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Aurelija JucaiteLars Farde
Sep 16, 1995·Lancet·G Sedvall, L Farde
Aug 30, 2007·Journal of Neural Transmission·J BernácerJ M Giménez-Amaya

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