Three-Dimensional Volumetric Segmentation of Pituitary Tumors: Assessment of Inter-rater Agreement and Comparison with Conventional Geometric Equations

Journal of Neurological Surgery. Part B, Skull Base
Karl LindbergDan Farahmand

Abstract

Background  The assessment of pituitary tumor (PT) volume is important in the treatment and follow-up of patients with PT. Previously, PT volume estimation has been performed by conventional geometric equations (CGE) such as abc/2 (simplified ellipsoid volume equation) and 4πr 3 /3 (sphere), both presuming a symmetric tumor shape, which occurs uncommonly in patients with PT. In contrast, three-dimensional (3D) voxel-based software segmentation takes the irregular and asymmetric shapes that PTs often possess into account and might be a more accurate method for PT volume segmentation. The purpose of this study is twofold. (1) To compare 3D segmentation with CGE for PT volume estimation. (2) To assess inter-rater reliability in 3D segmentation of PTs. Methods  Nineteen high-resolution (1mm slice thickness) T1-weighted MRI examinations of patients with PT were independently analyzed and manually segmented, using the software ITK-SNAP, by two certified neuroradiologists. Concurrently, the volumes of the PTs were estimated with abc/2 and 4πr 3 /3 by a clinician, and the results were compared with the corresponding segmented volumes. Results  There was a significant decrease in PT volume attained from the segmentations compared with t...Continue Reading

Citations

Dec 4, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joshua L AndersonAnthony J Cmelak
Jul 24, 2020·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Esther NellJessica Lawrence
Apr 30, 2019·Cancer Control : Journal of the Moffitt Cancer Center·Jie NiYong Li
Jun 2, 2021·The Journal of Clinical Endocrinology and Metabolism·He WangRenzhi Wang

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