Three dimensionally printed pearl powder/poly-caprolactone composite scaffolds for bone regeneration

Journal of Biomaterials Science. Polymer Edition
Xu ZhangBaoqing Yu

Abstract

Pearl has great potential as a natural biomaterial for bone tissue engineering, but it suffers from low porosity, difficulty in molding, and poor anti-buckling property. In this study, we used the 3-D printing technique to fabricate original pearl powder and PCL composite scaffolds with different concentrations of pearl powder. The four groups of scaffolds were termed PCL, 30% Pearl/PCL, 50% Pearl/PCL and 80% Pearl/PCL scaffolds according to the proportion of pearl powder. The samples were systematically investigated by scanning electron microscopy (SEM), wide-angle XRD, liquid substitution, Zwick static materials testing, and energy dispersive X-ray analysis. Biological characterization included SEM, fluorescent staining using calcein-AM, cell counting kit-8 assay, alkaline phosphatase and qRT-PCR analysis. The results show that the pore size and the pore morphology of the scaffolds are closely controlled via 3-D printing. This is very beneficial for tissue growth and nutrition transmission. The regular and uniform square macropore structure ensured that the pearl powder/PCL scaffolds had favorable mechanical strength. As the concentration of pearl powder in the scaffolds increase, the compressive strength and apatite formatio...Continue Reading

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Citations

Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rohaya Megat Abdul WahabFarinawati Yazid

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Methods Mentioned

BETA
X-ray

Software Mentioned

Bioplotter

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