PMID: 6984191Dec 1, 1982Paper

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3

Proceedings of the National Academy of Sciences of the United States of America
F Sanchez-MadridT A Springer

Abstract

Monoclonal antibodies were prepared to anti-HLA-DR cytolytic T lymphocytes (CTLs) and screened for inhibition of CTL-mediated killing. Binding of monoclonal antibodies to four types of molecules, LFA-1, LFA-2, LFA-3, and HLA-DR, inhibited killing, suggesting that these molecules participate in the CTL-target cell interaction. The antigens were characterized by immunoprecipitation, crosslinking, NaDodSO4/polyacrylamide gel electrophoresis, and immunofluorescence flow cytometry. The LFA-1 antigen contains alpha and beta polypeptide chains of Mr 177,000 and 95,000 that are noncovalently associated in an alpha 1 beta 1 structure. It is present on both B and T lymphocytes and marks subpopulations that differ in quantitative expression. Human LFA-1 appears to be the homologue of mouse LFA-1. Human LFA-2 is of Mr 49,000 with a minor component of Mr 36,000. It is expressed on CTL lines but not on a B-cell line and in peripheral blood preferentially on T lymphocytes. Human LFA-3 is of Mr 60,000 and is expressed on both B and T lymphocytes.

References

Apr 1, 1979·European Journal of Immunology·T SpringerC Milstein
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T W ChangG Goldstein
Oct 1, 1980·European Journal of Immunology·E L ReinherzS F Schlossman
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L EvansR A Good
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C S ReissS J Burakoff
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C D Platsoucas, R A Good
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M KrenskyS J Burakoff
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Oct 1, 1982·The Journal of Experimental Medicine·D I BellerR D Schreiber

❮ Previous
Next ❯

Citations

Sep 1, 1994·Arthritis and Rheumatism·B RichardsonK O'Rourke
Jan 8, 2005·Chembiochem : a European Journal of Chemical Biology·Karsten KöhlerRoland Brock
Mar 29, 2001·Journal of Surgical Oncology·A NaitoS Kobayashi
Jan 1, 1994·Archives of Dermatological Research·W H BoehnckeR Kaufmann
Jun 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·M M PekloE G Kolokol'chikova
Nov 1, 1992·The Histochemical Journal·M A Kerr, S C Stocks
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KoretzP Möller
Oct 1, 1992·Annals of Hematology·M A Reuss-BorstC A Müller
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·M J PalissonP Bischoff
Jan 1, 1990·Immunologic Research·R Lechler, G Lombardi
Jul 5, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nora PöntynenLeena Peltonen
Aug 1, 1988·Cellular Immunology·S J MentzerD V Faller
Dec 4, 1986·Journal of Immunological Methods·G D KeizerJ E De Vries
Dec 15, 1995·Journal of Immunological Methods·S J RothT A Springer
Nov 1, 1986·Molecular Immunology·R BurgerH Schaefer
Feb 25, 1992·Immunology Letters·J HunyadiA Dobozy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.