Three distinct families of GABAergic neurons in rat visual cortex

Cerebral Cortex
Yuri Gonchar, Andreas Burkhalter

Abstract

In the cortex inhibition is mediated predominantly by GABAergic interneurons. Although all of these neurons use the same neurotransmitter, studies in the rat frontal cortex have shown that they are molecularly and physiologically diverse. It is not known whether similar subgroups of GABAergic neurons exist in primary visual cortex and how these different inhibitory neurons are inserted into specific cortical circuits. We have used immunostaining with antibodies against gamma aminobutyric acid (GABA), parvalbumin (PV), calretinin (CR), somatostatin (SOM), calbindin (CB) and nitric oxide synthase (NOS) to probe for colocalization of known markers of GABAergic interneurons. The results show that the majority of PV (100%), SOM (89.8%) and CR (93.9%) staining neurons are GABA positive. PV immunoreactive neurons constitute a distinct group that show no overlap with CR, SOM and NOS expressing cells and only a minor overlap (5.3%) with CB. PV immunoreactive cells account for 50.8% of GABAergic neurons. A second group of SOM expressing neurons accounts for 16.9% of GABAergic cells. None of these cells colocalize PV or CR, but 1.7% of SOM neurons stain for NOS and 86.3% show CB immunoreactivity. The third distinct group of CR expressing ...Continue Reading

Citations

Jan 17, 2002·The Journal of Comparative Neurology·Yuri GoncharAndreas Burkhalter
Jan 27, 2005·Experimental Brain Research·Sébastien DesgentMaurice Ptito
Dec 3, 2011·Pflügers Archiv : European journal of physiology·Dominik Langer, Fritjof Helmchen
Nov 18, 2008·Brain Structure & Function·Chet C SherwoodPatrick R Hof
May 24, 2003·Brain Research. Developmental Brain Research·Neal R Melvin, Richard H Dyck
May 15, 2002·Brain Research. Molecular Brain Research·Masaaki HazamaShigetada Nakanishi
Dec 27, 2005·Nature Neuroscience·Elva Diaz
Jul 12, 2005·Nature Neuroscience·Inma CobosJohn L R Rubenstein
Dec 22, 2005·Nature Neuroscience·Ken SuginoSacha B Nelson
Aug 3, 2006·Nature Reviews. Neuroscience·Carl P Wonders, Stewart A Anderson
Mar 12, 2002·The European Journal of Neuroscience·Shuzo SakataYoshio Sakurai
Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kazuko SakataBai Lu
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hanno S MeyerMoritz Helmstaedter
Nov 19, 2008·Cerebral Cortex·Aleksey V ZaitsevDavid A Lewis
Apr 14, 2009·Cerebral Cortex·Vitor H SousaGord Fishell
Nov 19, 2010·Cerebral Cortex·Fu-Wen Zhou, Steven N Roper
Dec 20, 2011·Cerebral Cortex·Gisela ReinchisiNada Zecevic
Feb 24, 2012·Cerebral Cortex·Quentin PerrenoudThierry Gallopin

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