Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity

Phytotherapy Research : PTR
Hyung-In Moon

Abstract

To examine the cytoprotective effects of Leonurus japonicus Houtt, its protection against the glutamate-induced toxicity in primary cortical cultured neurons was tested. In order to clarify the cytoprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. By such fractionation, three known diterpenes--prehispanolone (1), leojaponin (2) and iso-preleoheterin (3)--were isolated from the methanol extracts from the air-dried L. japonicus. Among these three compounds, leojaponin (2) exhibited significant cytoprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microm to 10 microm. Therefore, the cytoprotective effect of L. japonicus might be due to the inhibition of glutamate-induced toxicity by the diterpenes it contains.

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Citations

Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jung-Hyun OhJin-Yong Lee
Nov 29, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fu PengXiao-Mei Zhao
Dec 5, 2015·Organic Letters·Liang XiongCheng Peng
Aug 7, 2020·The Journal of Pharmacy and Pharmacology·Grace Gar-Lee YueWei-Lie Xiao
Sep 11, 2019·Journal of Natural Products·Hang-Ying LiKun Gao

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