Three divisions of the mouse caudal striatum differ in the proportions of dopamine D1 and D2 receptor-expressing cells, distribution of dopaminergic axons, and composition of cholinergic and GABAergic interneurons

Brain Structure & Function
Yuta MiyamotoTakaichi Fukuda

Abstract

The greater part of the striatum is composed of striosomes and matrix compartments, but we recently demonstrated the presence of a region that has a distinct structural organization in the ventral half of the mouse caudal striatum (Miyamoto et al. in Brain Struct Funct 223:4275-4291, 2018). This region, termed the tri-laminar part based upon its differential immunoreactivities for substance P and enkephalin, consists of medial, intermediate, and lateral divisions. In this study, we quantitatively analyzed the distributions of both projection neurons and interneurons in each division using immunohistochemistry. Two types of projection neurons expressing either the dopamine D1 receptor (D1R) or D2 receptor (D2R) showed complementary distributions throughout the tri-laminar part, but the proportions significantly differed among the three divisions. The proportion of D1R-expressing neurons in the medial, intermediate, and lateral divisions was 88.6 ± 8.2% (651 cells from 3 mice), 14.7 ± 3.8% (1025 cells), and 49.3 ± 4.5% (873 cells), respectively. The intermediate division was further characterized by poor innervation of tyrosine hydroxylase immunoreactive axons. The numerical density of choline acetyltransferase immunoreactive neu...Continue Reading

References

Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C R GerfenJ J Miller
Jan 1, 1993·Progress in Brain Research·H Kita
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Jul 21, 1997·The Journal of Comparative Neurology·D J HoltC B Saper
Apr 3, 2007·Neurobiology of Learning and Memory·Raymond P Kesner, Paul E Gilbert
Aug 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kenta SatoSatoshi Goto
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wakoto MatsudaTakeshi Kaneko
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takaichi Fukuda
Jan 14, 2011·Frontiers in Neuroanatomy·James M TepperOsvaldo Ibáñez-Sandoval
Apr 8, 2011·Annual Review of Neuroscience·Charles R Gerfen, D James Surmeier
Sep 24, 2011·Frontiers in Neuroanatomy·Jill R Crittenden, Ann M Graybiel
Aug 4, 2012·Trends in Neurosciences·Aryn H Gittis, Anatol C Kreitzer
Mar 19, 2014·The Journal of Comparative Neurology·Makoto TakemotoWen-Jie Song
May 20, 2015·Brain : a Journal of Neurology·Hyoung F Kim, Okihide Hikosaka
Jun 21, 2016·Nature Neuroscience·Houri HintiryanHong-Wei Dong
Apr 20, 2018·Nature Communications·Lan GuoSantiago Jaramillo
May 19, 2018·Frontiers in Neuroanatomy·Haiyan Jiang, Hyoung F Kim
Sep 5, 2018·Nature Neuroscience·William MenegasMitsuko Watabe-Uchida

❮ Previous
Next ❯

Citations

Apr 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·J J Johannes HjorthSten Grillner
Nov 28, 2020·Trends in Neurosciences·Emmanuel Valjent, Giuseppe Gangarossa
Aug 10, 2021·Frontiers in Neural Circuits·Polina Kosillo, Helen S Bateup

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Software Mentioned

R
Image J
Neurolucida
CLSM

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Chronicle of Higher Education
Richard Monastersky
The Australian and New Zealand Journal of Surgery
G L Newstead
The Australian and New Zealand Journal of Surgery
I Faris
© 2021 Meta ULC. All rights reserved