Three ferritin subunit analogs in Chinese giant salamander (Andrias davidianus) and their response to microbial stimulation

Molecular Immunology
Xiuling YouZhiyong Liao

Abstract

Ferritin, an evolutionarily conserved iron-binding protein, plays important roles in iron storage and detoxification and in host immune response to invading stimulus as well. In the present study, we identified three ferritin subunit analog cDNAs from Chinese giant salamander (Andrias davidianus). All the three ferritin subunit cDNAs had a putative iron responsive element in the 5'-untranslated region. Two deduced ferritin subunits (designated as cgsFerH and cgsFerM) had the highest identity of 90% to H type subunit of vertebrate ferritins, while another deduced ferritin subunit (designated as cgsFerL) had the highest identity of 84% to L type subunit of vertebrate ferritins. The Chinese giant salamander ferritin (cgsFer) was widely expressed in various tissues, with highest expression for cgsFerH and cgsFerL in liver and highest expression for cgsFerM in spleen. Infection of Chinese giant salamander with A. davidianus ranavirus showed significant induction of cgsFer expression. Both lipopolysaccharide and iron challenge drastically augmented cgsFer expression in the splenocytes and hepatocytes from Chinese giant salamander. In addition, recombinant cgsFers bound to ferrous iron in a dose-dependent manner, with significant ferr...Continue Reading

References

Aug 15, 1992·Journal of Inorganic Biochemistry·S C AndrewsS J Yewdall
Nov 1, 1981·Reviews of Infectious Diseases·J J Bullen
Nov 15, 1994·The Biochemical Journal·E C Theil
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C Y BrownG J Goodall
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·A M ThomsonP J Leedman
Feb 15, 2002·Diseases of Aquatic Organisms·Q Y ZhangV G Chinchar
Mar 28, 2003·Nature·Ke-Qin Gao, Neil H Shubin
May 16, 2006·Immunobiology·Sek Tong OngJeak Ling Ding
May 22, 2007·RNA·Paul Piccinelli, Tore Samuelsson
Apr 2, 2008·Veterinary Immunology and Immunopathology·Zhong-Yuan ChenQi-Ya Zhang
Oct 22, 2008·Biochimica Et Biophysica Acta·Paolo ArosioPatrizia Cavadini
Mar 12, 2009·Biology of the Cell·Sangeeta Chatterjee, Jayanta K Pal
Jan 5, 2010·Fish & Shellfish Immunology·Pengfei KongLinsheng Song
May 13, 2010·Nucleic Acids Research·Monica CampillosMayka Sanchez
Feb 1, 2011·Developmental and Comparative Immunology·Jacques Robert, Nicholas Cohen
Dec 8, 2011·Fish & Shellfish Immunology·Juan LiGuofan Zhang
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 19, 2013·Immunity·Vincenzo Bronte, Mikael J Pittet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.