Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats

Toxicological Sciences : an Official Journal of the Society of Toxicology
R W TylGlenn S Simon

Abstract

This study evaluated the potential for dietary para-nonylphenol (NP; CAS No. 84852-15-3) to affect parental fertility and growth and development of three offspring generations in CD (Sprague-Dawley [SD]) rats, including sperm counts across generations to determine the validity of equivocal reductions observed in the F2 generation by R. E. Chapin et al. (1999, Toxicol. Sci. 52, 80-91). Male rat kidney toxicity was also examined based on inconsistent observations in NP-exposed rats at 2000 ppm but not at 200 or 650 ppm in Purina 5002 (H. C. Cunny et al., 1997, Regul. Toxicol. Pharmacol. 26, 172-178) and at all of these NP concentrations in NIH-07 diet (R. E. Chapin et al., 1999, Toxicol. Sci. 52, 80-91). Concentrations were 0, 20, 200, 650, and 2000 ppm NP in Purina 5002 diet and 0 and 650 ppm NP in NIH-07 diet. 17beta-estradiol (E2) was used as a positive control at 2.5 ppm in Purina 5002 diet. There were no NP effects on any reproductive parameters in any generation, including sperm counts. Kidney toxicity (histopathology) occurred at 650 and 2000 ppm with no clear difference for the two diets. Ovarian weight was decreased at 2000 ppm NP in all generations, with no effect on reproduction. Dietary E2 at 2.5 ppm caused renal, rep...Continue Reading

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Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough

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Citations

Nov 26, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ian C MunroShahrzad Tafazoli
Jan 11, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rochelle W TylSteven G Hentges
Feb 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donald G StumpSteven G Hentges
Jul 22, 2018·Journal of Applied Toxicology : JAT·Xiaomeng LiHuihui Bao
Jul 15, 2020·Andrologia·Mahdi MalmirHamideh Khodabandelo

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