Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo

Biological & Pharmaceutical Bulletin
T OikawaS Murota

Abstract

Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB, and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency as BB > AB = AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest that possibility that three PDGF isoforms are indirect angiogenic factors.

Citations

Aug 2, 2013·International Journal of Molecular Sciences·Nikos G GavalasAristotle Bamias
Jan 21, 2015·Expert Opinion on Investigational Drugs·Jennifer ArrondeauFrancois Goldwasser
Dec 3, 2014·Pharmacology & Therapeutics·Louise M HarknessJanette K Burgess
May 12, 2012·Critical Reviews in Oncology/hematology·A BamiasE Pujade-Lauraine
Jan 11, 2011·Gynecologic Oncology·Robert A Burger
Dec 30, 2014·Cancer Metastasis Reviews·Hyun-Jin ChoiAnil K Sood
Jun 9, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ruth Board, Gordon C Jayson
Jun 8, 2007·Blood Cells, Molecules & Diseases·Zaher K OtrockAli I Shamseddine
Jan 5, 2005·The Journal of Clinical Investigation·Xuri LiPeter Carmeliet
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Jamie C Mitchell, Sareh Parangi
Oct 18, 2011·Expert Review of Anticancer Therapy·Collin Blakely, Thierry Jahan
Mar 7, 2014·Expert Opinion on Pharmacotherapy·Sawsan Rashdan, Nasser Hanna
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Renhai CaoYuhai Cao
Jun 21, 2001·Endothelium : Journal of Endothelial Cell Research·J P HoddeS F Badylak
May 14, 2016·Molecular Medicine Reports·Wei-Ping ZhouYu-Feng Yao
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sachin M ApteIsaiah J Fidler

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