Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Stem Cell Research
Yuko AriokaNorio Ozaki

Abstract

Duplications at the 15q11.2-q13.1 region are associated with psychiatric disorders such as developmental delay and autism spectrum disorder. However, the specific influence of these duplications on human neuronal cells remains unclear. Here we generated induced pluripotent stem cells (iPSCs) derived from a patient with 15q11.2-q13.1 duplication syndrome. The generated iPSCs carried 15q11.2-q13.1 duplication and showed typical iPSC morphology and pluripotency marker expression, and the capacity to differentiate into three germ layers. These iPSC lines will contribute to further understanding the pathology of 15q11.2-q13.1 duplication syndrome and help develop drugs to treat psychiatric disorders.

Citations

Feb 18, 2020·Psychiatry and Clinical Neurosciences·Masahito SawahataNorio Ozaki
Nov 20, 2019·The Journal of Comparative Neurology·Kate M CandelarioDennis A Steindler
Jun 4, 2020·Molecular Autism·Danijela DrakulicAdrian J Harwood
Apr 11, 2020·Computational and Mathematical Methods in Medicine·Yanhui WangDazhi Meng

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