PMID: 8973673Dec 1, 1996Paper

Three-month depot of goserelin acetate: clinical efficacy and endocrine profile. Dutch South East Cooperative Urological Group

Urology
P Fernandez del MoralG J Kolvenbag

Abstract

To compare the pharmacodynamics and tolerability of the new goserelin acetate 10.8-mg depot with the 3.6-mg depot in patients with advanced prostate cancer during the first 3 months of therapy. One hundred sixty patients were randomized in two comparative studies to receive either the 10.8-mg goserelin acetate depot every 12 weeks or the 3.6-mg goserelin acetate depot every 4 weeks for 12 weeks and then the 10.8-mg depot every 12 weeks thereafter. Data for pharmacodynamic assessments were collected prospectively, whereas clinical response data were collected retrospectively. Serum testosterone profiles of the 10.8-mg goserelin acetate depot and the 3.6-mg goserelin acetate depot were similar; testosterone levels in both groups fell below castrate levels by day 21 after administration. Decreases in serum prostate-specific antigen level after 3 months of therapy were also similar in both groups: 94% with the 10.8-mg depot and 92.5% with the 3.6-mg depot. For all patients, the median time to progression was 152.7 weeks and the median time to death was 213.6 weeks. The safety profile of the 10.8-mg goserelin acetate depot was similar to that of the 3.6-mg depot; hot flashes was the most common adverse event. The incidence of inject...Continue Reading

Citations

Aug 5, 2000·Clinical Pharmacokinetics·I D Cockshott
Jan 8, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·S IannazzoM Perachino
Mar 18, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Naseem A Aziz, Chris F Heyns
Jul 17, 1999·British Journal of Cancer·C J Tyrrell

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