Three morphologically distinct types of interface develop between adult host and fetal brain transplants: implications for scar formation in the adult central nervous system

The Journal of Comparative Neurology
S KrügerM Berry

Abstract

The development of the host/graft interface of cerebellar and cerebral transplants was studied 1-60 days after operation. Grafts from fetal Wistar rats were transplanted to a cavity over the superior colliculus of adult rats by removing parts of the overlying cortex and hippocampus according to the Björklund/Stenevi technique. In sham-operated control rats, in which a cavity was made in the brain but no graft was implanted, the parenchyma bordering the entire cavity developed a complete glial-meningeal scar within 2 weeks after operation consisting of multilayered glial processes, a basal lamina, and fibroblasts (meningeal cells). A similar interface also developed between graft and host in the most superficial parts of the transplantation cavity. In the basal parts of the transplantation cavity, the host/graft interface consisted either of an incomplete sheet of astrocyte processes aligned in parallel to each other but without a covering basal lamina or of completely fused neuropil without any morphological signs of separation between host and transplant. It is concluded that these three zones of host/graft interface are established by differential interaction between the growing transplant and the host cicatrix. At the basal ...Continue Reading

References

Jan 1, 1977·Journal of Neuropathology and Experimental Neurology·C C KaoJ M Bloodworth
May 1, 1979·Biological Reviews of the Cambridge Philosophical Society·J A Kiernan
Feb 1, 1977·Journal of Neurosurgery· Kao tcc, L W chang
Feb 18, 1985·Brain Research·J J BernsteinM Kelemen
Feb 18, 1985·Brain Research·A J Mathewson, M Berry
Mar 1, 1983·The Journal of Cell Biology·P LiesiA Vaheri
Jan 1, 1984·Annual Review of Neuroscience·A Björklund, U Stenevi
Jan 1, 1983·Acta neurochirurgica. Supplementum·M BerryG H Thomas
Aug 1, 1983·Neuroscience·G Raisman, F F Ebner
Nov 1, 1983·Brain Research·P J ReierL Guth
Feb 1, 1984·The Journal of Comparative Neurology·J R Wujek, P J Reier
Jun 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P Liesi

❮ Previous
Next ❯

Citations

Aug 28, 1999·The Journal of Comparative Neurology·M M Tan, A R Harvey
Apr 24, 1991·Brain Research. Developmental Brain Research·K AbnetS B Dunnett
Jan 17, 1992·Brain Research. Developmental Brain Research·H F Zhou, R D Lund
Mar 20, 1992·Brain Research. Developmental Brain Research·J M RosensteinN H Sternberger
Jan 1, 1989·Brain Research Bulletin·G H Collins, N R West
Jan 1, 1989·Brain Research Bulletin·G H Collins, N R West
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J SieversM Puchner
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Mar 3, 1999·The European Journal of Neuroscience·C C StichelH W Müller
Apr 25, 2006·Journal of Neurotrauma·James W Fawcett
Sep 1, 1993·The European Journal of Neuroscience·L Schnell, M E Schwab
Oct 1, 1995·Brain Pathology·W F BlakemoreR J Franklin
Apr 1, 1993·Journal of Neurochemistry·G M SmithR H Miller
Mar 25, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Sean Dennis ChristieIvar Mendez
Jan 3, 2013·Trends in Molecular Medicine·Ravid Shechter, Michal Schwartz
Mar 22, 1988·The Journal of Comparative Neurology·J D Houlé, P J Reier
Jun 20, 2014·Brain Pathology·Francisco Fernández-Klett, Josef Priller
Dec 1, 1991·Experimental Neurology·R C SilvermanA J Silverman
Jun 16, 2006·Brain Research Reviews·Yona GoldshmitAnn Turnley
Sep 21, 2007·Mechanisms of Development·Anthony VuglerPeter Coffey
Jun 1, 2014·Brain Research Bulletin·Tianci ChuShiqing Feng
Mar 1, 1989·Experimental Neurology·J M Krum, J M Rosenstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.